ArticleNature communications2019
A shape-memory and spiral light-emitting device for precise multisite stimulation of nerve bundles.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 58 citations in OpenAlex.
- Weaving Intelligence: Thermally Drawn Multimaterial Fibers Toward AI-Enabled Smart Textiles.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Multi-site temporal control of optogenetic stimulation enhances firing frequencies in peripheral nerves.bioRxiv : the preprint server for biology · 2026Article
- A novel mouse model simulating C5 palsy after cervical surgery.Animal models and experimental medicine · 2026Article
- Shape memory hydrogels in tissue engineering: Recent advances and challenges.Bioactive materials · 2025Review
- Water-triggered self-wrapping and immobilization of an all-organic hydrogel-based cuff electrode.Materials today. Bio · 2025Article
- A wireless optogenetic stimulation system for long-term function evaluation of mice forelimb with sub-nerve resolution.Nature communications · 2025Article
- Design considerations for optogenetic applications of soft micro-LED-based device systems across diverse nervous systems.Bioactive materials · 2025Review
- Tentacle Microelectrode Arrays Uncover Soft Boundary Neurons in Hippocampal CA1.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Electrochemically actuated microelectrodes for minimally invasive peripheral nerve interfaces.Nature materials · 2024Article
- Myostatin regulates energy homeostasis through autocrine- and paracrine-mediated microenvironment communication.The Journal of clinical investigation · 2024Article
- Shape Memory Hydrogels for Biomedical Applications.Gels (Basel, Switzerland) · 2024Review
- Bionic artificial skin with a fully implantable wireless tactile sensory system for wound healing and restoring skin tactile function.Nature communications · 2024Article
- Soft ferroelectret ultrasound receiver for targeted peripheral neuromodulation.Nature communications · 2023Article
- Fatigue-resistant hydrogel optical fibers enable peripheral nerve optogenetics during locomotion.Nature methods · 2023Article
- Emerging trends in the development of flexible optrode arrays for electrophysiology.APL bioengineering · 2023Review
- Integrated opposite charge grafting induced ionic-junction fiber.Nature communications · 2023Article
- Synthesizing Metal Oxide Semiconductors on Doped Si/SiOResearch (Washington, D.C.) · 2023Article
- Elastic Fibers/Fabrics for Wearables and Bioelectronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- Benefits of a Skull-Interfaced Flexible and Implantable Multilight Emitting Diode Array for Photobiomodulation in Ischemic Stroke.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Flexible Electronics and Devices as Human-Machine Interfaces for Medical Robotics.Advanced materials (Deerfield Beach, Fla.) · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 2 institutions in 2 countries.
Funding
Abstract
We previously demonstrated that for long-term spastic limb paralysis, transferring the seventh cervical nerve (C7) from the nonparalyzed side to the paralyzed side results in increase of 17.7 in Fugl-Meyer score. One strategy for further improvement in voluntary arm movement is selective activation of five target muscles innervated by C7 during recovery process. In this study, we develop an implantable multisite optogenetic stimulation device (MOSD) based on shape-memory polymer. Two-site stimulation of sciatic nerve bundles by MOSD induces precise extension or flexion movements of the ankle joint, while eight-site stimulation of C7 nerve bundles induce selective limb movement. Long-term implant of MOSD to mice with severed and anastomosed C7 nerve is proven to be both safe and effective. Our work opens up the possibility for multisite nerve bundle stimulation to induce highly-selective activations of limb muscles, which could inspire further applications in neurosurgery and neuroscience research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.