Evidence map›Paper›PMID 31243125›Full record

ArticleJournal of virology2019

Disrupted CXCR2 Signaling in Oligodendroglia Lineage Cells Enhances Myelin Repair in a Viral Model of Multiple Sclerosis.

Brett S Marro, Dominic D Skinner, Yuting Cheng, Jonathan J Grist, Laura L Dickey, Emily Eckman, Colleen Stone, Liping Liu, Richard M Ransohoff, Thomas E Lane

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Gasdermin D kills bacteria.Microbiological research · 2023
    Review
  6. Article
  7. Article
  8. Article
  9. Mass Cytometry of CSF Identifies an MS-Associated B-cell Population.Neurology(R) neuroimmunology & neuroinflammation · 2021
    Article
  10. Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Brett S Marro *Department of Molecular Biology & Biochemistry, University of California, Irvine, Irvine, California, USA.
Dominic D Skinner *Division of Microbiology & Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Yuting ChengDivision of Microbiology & Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Jonathan J GristDivision of Microbiology & Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Laura L DickeyDivision of Microbiology & Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Emily EckmanDivision of Microbiology & Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Colleen StoneDivision of Microbiology & Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Liping LiuLerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Richard M RansohoffDepartment of Cell Biology, Harvard University School of Medicine, Boston, Massachusetts, USA.
Thomas E LaneDivision of Microbiology & Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, USA tom.lane@path.utah.edu.
University of Utah · USCleveland Clinic Lerner College of Medicine · USHarvard University · USUniversity of California, Irvine · US

Funding

Utah Center for Clinical and Translational ScienceUL1TR002538 · NCATS · UNIVERSITY OF UTAH · PI HESS, RACHEL, MAJERSIK, JENNIFER JUHL · 2018 to 2022
$26.0M
Chemokines and Viral-Induced Neurologic DiseaseR01NS041249 · NINDS · UNIVERSITY OF UTAH · PI LANE, THOMAS E · 2002 to 2019
$5.4M
CHEMOKINES IN CNS INFLAMMATIONR01NS032151 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI RANSOHOFF, RICHARD M. · 1994 to 2013
$3.7M
NCATS NIH HHS UL1 TR002538NINDS NIH HHS R01 NS032151NINDS NIH HHS R01 NS041249
6 · The paper itself

Abstract

CXCR2 is a chemokine receptor expressed on oligodendroglia that has been implicated in the pathogenesis of neuroinflammatory demyelinating diseases as well as enhancement of the migration, proliferation, and myelin production by oligodendroglia. Using an inducible proteolipid protein (

Indexed as

AnimalsAxonsCell DifferentiationCell LineCentral Nervous SystemDemyelinating DiseasesDisease Models, AnimalHumansMiceMice, TransgenicMultiple SclerosisMurine hepatitis virusMyelin SheathNeurogliaOligodendrogliaReceptors, Interleukin-8BCXCR2 protein, humanReceptors, Interleukin-8BTamoxifenchemokine receptorsdemyelinationoligodendrocyteremyelinationvirus

Identifiers

PMID31243125
PMCPMC6714798
OpenAlexW2949623841

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.