ArticleCancer genomics & proteomics
Contribution of Matrix Metalloproteinase-2 Promoter Genotypes to Nasopharyngeal Cancer Susceptibility and Metastasis in Taiwan.
Article in Cancer genomics & proteomics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Contribution of Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 to Upper Tract Urothelial Cancer Risk in Taiwan.Life (Basel, Switzerland) · 2024Article
- Analysis ofInternational journal of molecular sciences · 2023Article
- Significant Association of Interleukin-16 Genetic Variations to Taiwanese Lung Cancer.In vivo (Athens, Greece)Article
- Interaction of Interleukin-16 Genotypes With Betel Quid Chewing Behavior on Oral Cancer in Taiwan.In vivo (Athens, Greece)Article
- Significant Association of MMP2 Promoter Genotypes to Asthma Susceptibility in Taiwan.In vivo (Athens, Greece)Article
- Association ofIn vivo (Athens, Greece)Article
- Association of Matrix Metalloproteinase-7 Genotypes With Nasopharyngeal Carcinoma Risk.In vivo (Athens, Greece)Article
- Association of Murine Double Minute 2 Genotypes and Lung Cancer Risk.In vivo (Athens, Greece)Article
- The Significant Interaction of Excision Repair Cross-complementing Group 1 Genotypes and Smoking to Lung Cancer Risk.Cancer genomics & proteomicsObservational
- Association of Interleukin-4 Polymorphisms With Breast Cancer in Taiwan.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimMatrix metalloproteinase 2 (MMP2) is up-regulated in many cancers. However, the association of MMP2 genotype to nasopharyngeal cancer (NPC) susceptibility in Taiwan remains elusive. MATERIALS AND
methodsIn this study, the role of MMP2 promoter C-1306T (rs243865) and C-735T (rs2285053) genotypes were investigated among 208 NPC patients and 416 healthy controls, and their role in NPC staging and TNM classifications were examined.
resultsThere was no differential distribution as for the genotypic or allelic frequencies at MMP2 promoter C-1306T or C-735T between the control and case groups. Noticeably, those with MMP2 C-1306T CT+TT genotypes had a lower metastatic risk than those with CC (p=0.0295). As for staging, T and N classifications, there was no differential distribution in C-1306T genotypes (p>0.05). Also, there was no differential distribution of C-735T genotypes according to different behavioral/clinicopathological characteristics.
conclusionCT and TT genotypes at MMP2 C-1306T were associated with a significantly decreased risk of NPC metastasis.
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