Evidence map›Paper›PMID 31243105›Full record

ArticleCancer genomics & proteomics

The Association of a Novel Identified

Mohammad R Daremipouran, Desta Beyene, Victor Apprey, Tammey J Naab, Olakunle O Kassim, Robert L Copeland, Yasmine M Kanaan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer genomics & proteomics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
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  5. Article
  6. Article
  7. A Allele ofOpen life sciences · 2019
    Article
  8. The Association Between the GeneticCancer genomics & proteomics
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mohammad R DaremipouranCancer Center, Howard University, Washington, DC, U.S.A.
Desta BeyeneCancer Center, Howard University, Washington, DC, U.S.A.
Victor AppreyCommunity and Family Medicine, College of Medicine, Howard University, Washington, DC, U.S.A.
Tammey J NaabDepartment of Pathology, College of Medicine, Howard University, Washington, DC, U.S.A.
Olakunle O KassimDepartment of Microbiology, College of Medicine, Howard University, Washington, DC, U.S.A.
Robert L CopelandCancer Center, Howard University, Washington, DC, U.S.A.
Yasmine M KanaanCancer Center, Howard University, Washington, DC, U.S.A. ymkanaan@howard.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimVitamin D receptor (VDR) is present in numerous cellular pathways and it has been suggested that VDR genetic variants influence individual susceptibility to prostate cancer. Also, analyses of single nucleotide polymorphisms (SNPs) in VDR revealed ethnicity-associated polymorphisms. The aim of this study was to identify VDR SNPs in African American men with and without prostate cancer. MATERIALS AND

methodsThe entire VDR gene was screened for germline mutations in a case-control study by denaturing high performance liquid chromatography and DNA sequencing. Logistic regression was used to estimate the association of SNPs, age, family history, and Gleason score with prostate cancer risk.

resultsSix SNPs in the non-coding regions, and one SNP in the coding region, were detected. SNP 1 (c.278-69G>A) and SNP 4 (c.907+75C>T) have not been previously reported. SNP 4 had a significant protective effect (β=-0.6, p<0.05); whereas, SNP 7 (rs7975232) showed an increase association with prostate cancer risk and high Gleason score (β=0.32, p<0.05). SNP 4, SNP 7 and age were better predictors of prostate cancer risk than family history with a high degree of sensitivity (74.7%) and specificity (92.4%).

conclusionSNP 4 and SNP 7 could be promising markers for prediction of reduced or increased prostate cancer risk, respectively.

Indexed as

AgedBlack or African AmericanHumansMaleMiddle AgedPolymorphism, Single NucleotideProstatic NeoplasmsReceptors, CalcitriolReceptors, CalcitriolVDR protein, humanAfrican American menProstate cancersingle nucleotide polymorphismvitamin Dvitamin D receptor gene

Identifiers

PMID31243105
PMCPMC6609256

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.