Evidence map›Paper›PMID 31243087›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2019

Identification of an Intronic Regulatory Element Necessary for Tissue-Specific Expression of

Brian M Larsen, Jennifer E Cowan, Yueqiang Wang, Yu Tanaka, Yongge Zhao, Benjamin Voisin, Michael G Constantinides, Keisuke Nagao, Yasmine Belkaid, Parirokh Awasthi and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Zoological research · 2025
    Article
  3. Review
  4. Thymus Ontogeny and Development.Advances in experimental medicine and biology · 2025
    Review
  5. Topoisomerase 1 is required for the development and function of thymus.Journal of immunology (Baltimore, Md. : 1950) · 2025
    Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. A 2020 View of Thymus Stromal Cells in T Cell Development.Journal of immunology (Baltimore, Md. : 1950) · 2021
    Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Brian M LarsenLaboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.ORCID 0000-0002-4103-4990
Jennifer E CowanLaboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Yueqiang WangLaboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.ORCID 0000-0002-9246-0877
Yu TanakaExperimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Yongge ZhaoLaboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.ORCID 0000-0003-4466-2391
Benjamin VoisinDermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892.
Michael G ConstantinidesMetaorganism Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; and.ORCID 0000-0003-4770-7751
Keisuke NagaoDermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892.ORCID 0000-0002-7005-3138
Yasmine BelkaidMetaorganism Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; and.
Parirokh AwasthiLaboratory Animal Sciences Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, National Institutes of Health, Frederick, MD 21701.
Yousuke TakahamaExperimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Avinash BhandoolaLaboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; avinash.bhandoola@nih.gov.ORCID 0000-0002-4657-8372
National Institutes of Health · USLeidos (United States) · US

Funding

T cell Development and RegenerationZIABC011633 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI BHANDOOLA, AVINASH · 2015 to 2025
$20.5M
Exploring mechanisms that govern immune homeostasis in skinZIABC011561 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI NAGAO, KEISUKE · 2014 to 2021
$10.1M
Role of Tissue-Specific Factors in the Control of ImmunityZIAAI001132 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI BELKAID, YASMINE · 2011 to 2025
$6.4M
Intramural NIH HHS Z99 CA999999Intramural NIH HHS ZIA BC011633
6 · The paper itself

Abstract

The thymus is critical for the establishment of the adaptive immune system and the development of a diverse T cell repertoire. T cell development depends upon cell-cell interactions with epithelial cells in the thymus. The thymus is composed of two different types of epithelial cells: cortical and medullary epithelial cells. Both of these express and critically depend on the transcription factor

Indexed as

AnimalsEpithelial CellsForkhead Transcription FactorsGene Expression RegulationGene Knockout TechniquesHair FollicleMiceMice, KnockoutMice, NudeRegulatory Elements, TranscriptionalRNA, MessengerThymus GlandT-LymphocytesForkhead Transcription FactorsRNA, MessengerWhn protein

Identifiers

PMID31243087
PMCPMC6650349
OpenAlexW2953899230

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.