Evidence map›Paper›PMID 31243060›Full record

ArticleMolecular pharmacology2019

Identification of Abundant and Evolutionarily Conserved Opioid Receptor Circular RNAs in the Nervous System Modulated by Morphine.

Takeshi Irie, Rebecca Shum, Ioanna Deni, Amanda Hunkele, Valerie Le Rouzic, Jin Xu, Roger Wilson, Gregory W Fischer, Gavril W Pasternak, Ying-Xian Pan

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Circular RNA regulation and function in drug seeking phenotypes.Molecular and cellular neurosciences · 2023
    Review
  4. Review
  5. Article
  6. Epigenetic Modulation of Opioid Receptors by Drugs of Abuse.International journal of molecular sciences · 2022
    Review
  7. Heroin Regulates Orbitofrontal Circular RNAs.International journal of molecular sciences · 2022
    Article
  8. Noncoding RNA therapeutics for substance use disorder.Advances in drug and alcohol research · 2022
    Article
  9. Role of circRNAs in neurodevelopment and neurodegenerative diseases.Journal of molecular neuroscience : MN · 2021
    Review
  10. The Roles of CircRNAs in Regulating Muscle Development of Livestock Animals.Frontiers in cell and developmental biology · 2021
    Review
  11. Article
  12. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Takeshi IrieDepartments of Anesthesiology and Critical Care Medicine (T.I., R.W., G.W.F.) and Neurology (G.W.P., Y.-X.P.), and Molecular Pharmacology Program (R.S., I.D., A.H., V.L.R., J.X., G.W.P.), Memorial Sloan-Kettering Cancer Center, New York, New York.
Rebecca ShumDepartments of Anesthesiology and Critical Care Medicine (T.I., R.W., G.W.F.) and Neurology (G.W.P., Y.-X.P.), and Molecular Pharmacology Program (R.S., I.D., A.H., V.L.R., J.X., G.W.P.), Memorial Sloan-Kettering Cancer Center, New York, New York.
Ioanna DeniDepartments of Anesthesiology and Critical Care Medicine (T.I., R.W., G.W.F.) and Neurology (G.W.P., Y.-X.P.), and Molecular Pharmacology Program (R.S., I.D., A.H., V.L.R., J.X., G.W.P.), Memorial Sloan-Kettering Cancer Center, New York, New York.ORCID 0000-0002-5266-8243
Amanda HunkeleDepartments of Anesthesiology and Critical Care Medicine (T.I., R.W., G.W.F.) and Neurology (G.W.P., Y.-X.P.), and Molecular Pharmacology Program (R.S., I.D., A.H., V.L.R., J.X., G.W.P.), Memorial Sloan-Kettering Cancer Center, New York, New York.
Valerie Le RouzicDepartments of Anesthesiology and Critical Care Medicine (T.I., R.W., G.W.F.) and Neurology (G.W.P., Y.-X.P.), and Molecular Pharmacology Program (R.S., I.D., A.H., V.L.R., J.X., G.W.P.), Memorial Sloan-Kettering Cancer Center, New York, New York.
Jin XuDepartments of Anesthesiology and Critical Care Medicine (T.I., R.W., G.W.F.) and Neurology (G.W.P., Y.-X.P.), and Molecular Pharmacology Program (R.S., I.D., A.H., V.L.R., J.X., G.W.P.), Memorial Sloan-Kettering Cancer Center, New York, New York.
Roger WilsonDepartments of Anesthesiology and Critical Care Medicine (T.I., R.W., G.W.F.) and Neurology (G.W.P., Y.-X.P.), and Molecular Pharmacology Program (R.S., I.D., A.H., V.L.R., J.X., G.W.P.), Memorial Sloan-Kettering Cancer Center, New York, New York.
Gregory W FischerDepartments of Anesthesiology and Critical Care Medicine (T.I., R.W., G.W.F.) and Neurology (G.W.P., Y.-X.P.), and Molecular Pharmacology Program (R.S., I.D., A.H., V.L.R., J.X., G.W.P.), Memorial Sloan-Kettering Cancer Center, New York, New York.
Gavril W PasternakDepartments of Anesthesiology and Critical Care Medicine (T.I., R.W., G.W.F.) and Neurology (G.W.P., Y.-X.P.), and Molecular Pharmacology Program (R.S., I.D., A.H., V.L.R., J.X., G.W.P.), Memorial Sloan-Kettering Cancer Center, New York, New York.
Ying-Xian PanDepartments of Anesthesiology and Critical Care Medicine (T.I., R.W., G.W.F.) and Neurology (G.W.P., Y.-X.P.), and Molecular Pharmacology Program (R.S., I.D., A.H., V.L.R., J.X., G.W.P.), Memorial Sloan-Kettering Cancer Center, New York, New York pany@mskcc.org.
Memorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
TRAINING IN BEHAV. PHARMACOLOGY OF HUMAN DRUG DEPENDENCET32DA007242 · NIDA · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI HEIL, SARAH H, HIGGINS, STEPHEN T · 1990 to 2025
$8.2M
Synthesis &Pharmacology of Novel Opiates and SystemsR01DA006241 · NIDA · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI PAN, YING-XIAN · 1990 to 2018
$6.4M
PHARMACOLOGY OF OPIOID RECEPTOR SUBTYPESR01DA007242 · NIDA · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI PAN, YING-XIAN · 1991 to 2022
$6.0M
Alternative pre-mRNA splicing of mu opioid receptor gene and mu opioid actionsR01DA042888 · NIDA · SLOAN-KETTERING INST CAN RESEARCH · PI PAN, YING-XIAN · 2017 to 2021
$1.9M
PHARMACOLOGY OF OPIOID RECEPTOR SUBTYPESR37DA007242 · NIDA · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI PASTERNAK, GAVRIL W · 1996 to 2004
$1.5M
Mapping mu agonist-induced receptor-protein interactions for OPRM1 7TM variantsR21DA046714 · NIDA · SLOAN-KETTERING INST CAN RESEARCH · PI PAN, YING-XIAN · 2018 to 2019
$502k
Exploring function of mu opioid receptor splice variants in rat by gene targetingR21DA040858 · NIDA · SLOAN-KETTERING INST CAN RESEARCH · PI PAN, YING-XIAN · 2016 to 2017
$471k
NCI NIH HHS P30 CA008748NIDA NIH HHS R01 DA006241NIDA NIH HHS R01 DA007242NIDA NIH HHS R01 DA042888NIDA NIH HHS R21 DA040858NIDA NIH HHS R21 DA046714NIDA NIH HHS R37 DA007242NIDA NIH HHS T32 DA007242
6 · The paper itself

Abstract

Circular RNAs (circRNAs) are a distinct category of single-stranded, covalently closed RNAs formed by backsplicing. The functions of circRNAs are incompletely known and are under active investigation. Here, we report that in addition to traditional linear mRNAs (linRNA), mouse, rat, and human opioid receptor genes generate exonic circRNA isoforms. Using standard molecular biologic methods,

Indexed as

AnimalsBrainCell Line, TumorConserved SequenceGene Expression ProfilingGene Expression RegulationHumansMaleMiceMorphineNeuroblastomaRatsReceptors, Opioid, muRNA, CircularSequence Analysis, RNASpinal CordMorphineReceptors, Opioid, muRNA, Circular

Identifiers

PMID31243060
PMCPMC6666384
OpenAlexW2953869247

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.