Evidence map›Paper›PMID 31243036›Full record

ArticleBMJ open2019

Assessing the relationship between near-infrared spectroscopy-derived regional cerebral oxygenation and neurological dysfunction in critically ill adults: a prospective observational multicentre protocol, on behalf of the Canadian Critical Care Trials Group.

Michael D Wood, Jasmine Khan, Kevin F H Lee, David M Maslove, John Muscedere, Miranda Hunt, Stephen H Scott, Andrew Day, Jill A Jacobson, Ian Ball and 7 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03141619 (Cerebral Oxygenation and Neurological Outcomes FOllowing CriticAL Illness-2), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03141619 unknown statusnot on this map

Cerebral Oxygenation and Neurological Outcomes FOllowing CriticAL Illness-2

TypeobservationalSponsorDr. Gordon BoydRan2017 to 2025Enrolled500ConditionsCritical Illness, Respiratory Failure, Shock, Delirium
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Michael D WoodCentre For Neuroscience Studies, Queen's University, Kingston, Ontario, Canada.
Jasmine KhanCentre For Neuroscience Studies, Queen's University, Kingston, Ontario, Canada.
Kevin F H LeeSchool of Medicine, Queen's University, Kingston, Ontario, Canada.
David M MasloveCritical Care Medicine, Queen's University, Kingston, Ontario, Canada.
John MuscedereCritical Care Medicine, Kingston General Hospital, Kingston, Ontario, Canada.
Miranda HuntCritical Care Medicine, Queen's University, Kingston, Ontario, Canada.
Stephen H ScottCentre For Neuroscience Studies, Queen's University, Kingston, Ontario, Canada.
Andrew DayDepartment of Community Health and Epidemiology and CERU, Queen's University, Kingston, Ontario, Canada.
Jill A JacobsonPsychology, Queen's University, Kingston, Ontario, Canada.
Ian BallMedicine, London Health Sciences Centre, London, Ontario, Canada.
Marat SlessarevMedicine, Division of Geriatric Medicine, Western University, London, Ontario, Canada.
Niamh O'ReganMedicine, Division of Geriatric Medicine, Western University, London, Ontario, Canada.
Shane W EnglishMedicine (Critical Care), University of Ottawa, Ottawa, Ontario, Canada.ORCID 0000-0002-9477-6146
Victoria McCredieMedicine; Critical Care, University of Toronto; Toronto Western Hospital, University Health Network, Toronto, Canada.
Michaël ChasseMedicine (Critical Care), Centre Hospitalier de L'Universite de Montreal, Montréal, Quebec, Canada.
Donald GriesdaleDepartment of Anesthesiology, Pharmacology & Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada.
J Gordon BoydCritical Care Medicine, Kingston General Hospital, Kingston, Ontario, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSurvivors of critical illness frequently exhibit acute and chronic neurological complications. The underlying aetiology of this dysfunction remains unknown but may be associated with cerebral ischaemia. This study will use near-infrared spectroscopy to non-invasively quantify regional cerebral oxygenation (rSO METHODS AND ANALYSIS: This multicentre prospective observational study will consider adult patients (≥18 years old) eligible for enrolment if within 24 hours of ICU admission, they require mechanical ventilation and/or vasopressor support. For 72 hours, rSO ETHICS AND DISSEMINATION: The study protocol has been approved in Ontario by a central research ethics board (Clinical Trials Ontario); non-Ontario sites will obtain local ethics approval. The study will be conducted under the guidance of the Canadian Critical Care Trials Group (CCCTG) and the results of this study will be presented at national meetings of the CCCTG for internal peer review. Results will also be presented at national/international scientific conferences. On completion, the study findings will be submitted for publication in peer-reviewed journals. TRIAL REGISTRATION NUMBER: NCT03141619.

Indexed as

BrainCognitive DysfunctionDeliriumAdultCanadaCerebrovascular CirculationCritical CareCritical IllnessFemaleHumansMaleMulticenter Studies as TopicObservational Studies as TopicOxygen ConsumptionSeverity of Illness IndexSpectroscopy, Near-Infraredcerebral autoregulationdeliriumkinarmnear-infrared spectroscopypost-intensive care syndromerbans

Identifiers

PMID31243036
PMCPMC6597627

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.