Observational studyArchives of disease in childhood2019
Neuroimaging findings in newborns with congenital heart disease prior to surgery: an observational study.
Observational study in Archives of disease in childhood, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Paediatric brain MRI findings following congenital heart surgery: a systematic review.Archives of disease in childhood · 2022Pooled it
- Neonatal brain structure, cognitively stimulating parenting and behavioural outcomes in preschool children with congenital heart disease and controls.Scientific reports · 2026Article
- Long-Term Outcome Following Prenatal Diagnosis of Transposition of the Great Arteries.Pediatric cardiology · 2026Article
- The Sooner, the Better: Neuroprotective Strategies in Fetuses With Congenital Heart Disease.Prenatal diagnosis · 2026Review
- Hippocampal morphometry is altered in infants with congenital heart disease.Brain communications · 2026Article
- Neurodevelopment in congenital heart disease: a review of antenatal mechanisms and therapeutic potentials.Pediatric research · 2025Review
- Acute ventriculomegaly and gaze deviation after evacuation of subdural hematoma: report of an unusual case.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Article
- Foetal disruptive brain injuries: Diagnosing the underlying pathogenetic mechanisms with cranial ultrasonography.Developmental medicine and child neurology · 2025Review
- Similarities and differences in cerebellar alterations between youth born preterm and youth born with congenital heart disease.Scientific reports · 2025Article
- Perioperative Brain Injury in Children with Aortic Arch Anomalies: A Retrospective Study of Risk Factors and Outcomes.Pediatric cardiology · 2024Article
- Effects of Prostaglandin E1 and Balloon Atrial Septostomy on Cerebral Blood Flow and Oxygenation in Newborns Diagnosed with Transposition of the Great Arteries.Biomedicines · 2024Article
- Total and Regional Brain Volumes in Fetuses With Congenital Heart Disease.Journal of magnetic resonance imaging : JMRI · 2024Article
- Executive Function in Preschool Children with Congenital Heart Disease and Controls: The Role of a Cognitively Stimulating Home Environment.The Journal of pediatrics · 2024Article
- A pre-existing Toxoplasma gondii infection exacerbates the pathophysiological response and extent of brain damage after traumatic brain injury in mice.Journal of neuroinflammation · 2024Article
- Individualized cortical gyrification in neonates with congenital heart disease.Brain communications · 2024Article
- Individual Assessment of Perioperative Brain Growth Trajectories in Infants With Congenital Heart Disease: Correlation With Clinical and Surgical Risk Factors.Journal of the American Heart Association · 2023Article
- Neurometabolic changes in neonates with congenital heart defects and their relation to neurodevelopmental outcome.Pediatric research · 2023Article
- Practice variations for fetal and neonatal congenital heart disease within the Children's Hospitals Neonatal Consortium.Pediatric research · 2023Article
- Neuromonitoring, neuroimaging, and neurodevelopmental follow-up practices in neonatal congenital heart disease: a European survey.Pediatric research · 2023Article
- Risk Factors for Perioperative Brain Lesions in Infants With Congenital Heart Disease: A European Collaboration.Stroke · 2022Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesNeurodevelopmental impairment has become the most important comorbidity in infants with congenital heart disease (CHD). We aimed to (1) investigate the burden of brain lesions in infants with CHD prior to surgery and (2) explore clinical factors associated with injury. STUDY
designProspective observational study.
settingSingle centre UK tertiary neonatal intensive care unit. PATIENTS: 70 newborn infants with critical or serious CHD underwent brain MRI prior to surgery.
main outcome measuresPrevalence of cerebral injury including arterial ischaemic strokes (AIS), white matter injury (WMI) and intracranial haemorrhage.
resultsBrain lesions were observed in 39% of subjects (95% CI 28% to 50%). WMI was identified in 33% (95% CI 23% to 45%), subdural haemorrhage without mass effect in 33% (95% CI 23% to 45%), cerebellar haemorrhage in 9% (95% CI 4% to 18%) and AIS in 4% (95% CI 1.5% to 12%). WMI was distributed widely throughout the brain, particularly involving the frontal white matter, optic radiations and corona radiata. WMI exhibited restricted diffusion in 48% of cases. AIS was only observed in infants with transposition of the great arteries (TGA) who had previously undergone balloon atrial septostomy (BAS). AIS was identified in 23% (95% CI 8% to 50%) of infants with TGA who underwent BAS, compared with 0% (95% CI 0% to 20%) who did not.
conclusionsCerebral injury in newborns with CHD prior to surgery is common.
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Registered trials
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