Evidence map›Paper›PMID 31243001›Full record

ArticleBMJ (Clinical research ed.)2019

Investigating causal relations between sleep traits and risk of breast cancer in women: mendelian randomisation study.

Rebecca C Richmond, Emma L Anderson, Hassan S Dashti, Samuel E Jones, Jacqueline M Lane, Linn Beate Strand, Ben Brumpton, Martin K Rutter, Andrew R Wood, Kurt Straif and 8 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ (Clinical research ed.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 8 pooled it
12.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 8 syntheses or guidelines pooled it, 171 citations in OpenAlex.

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  18. Optimal sleep timing revealed: a new perspective on reducing all-cause mortality and cardiovascular disease-cause mortality in older adults.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
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25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 4 countries.

Rebecca C RichmondMRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK Rebecca.richmond@bristol.ac.uk.ORCID http://orcid.org/0000-0003-0574-5071
Emma L AndersonMRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.
Hassan S DashtiCentre for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Samuel E JonesGenetics of Complex Traits, University of Exeter Medical School, Exeter, UK.
Jacqueline M LaneCentre for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Linn Beate StrandK.G. Jebsen Centre for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health sciences, Norwegian University of Science and Technology, NTNU, Trondheim, Norway.
Ben BrumptonK.G. Jebsen Centre for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health sciences, Norwegian University of Science and Technology, NTNU, Trondheim, Norway.
Martin K RutterDivision of Endocrinology, Diabetes and Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Andrew R WoodGenetics of Complex Traits, University of Exeter Medical School, Exeter, UK.
Kurt StraifInternational Agency for Research on Cancer, Lyon, France.
Caroline L ReltonMRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.
Marcus MunafòMRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.
Timothy M FraylingGenetics of Complex Traits, University of Exeter Medical School, Exeter, UK.
Richard M MartinMRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.
Richa SaxenaCentre for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Michael N WeedonGenetics of Complex Traits, University of Exeter Medical School, Exeter, UK.
Debbie A LawlorMRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.
George Davey SmithMRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.
University of Bristol · GBUniversity of Exeter · GBBroad Institute · USUniversity Hospitals Bristol NHS Foundation Trust · GBNorwegian University of Science and Technology · NOCentre international de recherche sur le cancer · FRManchester Academic Health Science Centre · GB

Funding

Cancer Research UK 19169Medical Research Council MC_PC_17228Medical Research Council MC_QA137853Medical Research Council MC_UU_00011/1Medical Research Council MC_UU_00011/2Medical Research Council MC_UU_00011/5Medical Research Council MC_UU_00011/6Medical Research Council MC_UU_00011/7Medical Research Council MR/M005070/1Medical Research Council MR/P012167/1Medical Research Council MR/P014437/1World Health Organization 001
6 · The paper itself

Abstract

objectiveTo examine whether sleep traits have a causal effect on risk of breast cancer.

designMendelian randomisation study.

settingUK Biobank prospective cohort study and Breast Cancer Association Consortium (BCAC) case-control genome-wide association study.

participants156 848 women in the multivariable regression and one sample mendelian randomisation (MR) analysis in UK Biobank (7784 with a breast cancer diagnosis) and 122 977 breast cancer cases and 105 974 controls from BCAC in the two sample MR analysis. EXPOSURES: Self reported chronotype (morning or evening preference), insomnia symptoms, and sleep duration in multivariable regression, and genetic variants robustly associated with these sleep traits.

main outcome measureBreast cancer diagnosis.

resultsIn multivariable regression analysis using UK Biobank data on breast cancer incidence, morning preference was inversely associated with breast cancer (hazard ratio 0.95, 95% confidence interval 0.93 to 0.98 per category increase), whereas there was little evidence for an association between sleep duration and insomnia symptoms. Using 341 single nucleotide polymorphisms (SNPs) associated with chronotype, 91 SNPs associated with sleep duration, and 57 SNPs associated with insomnia symptoms, one sample MR analysis in UK Biobank provided some supportive evidence for a protective effect of morning preference on breast cancer risk (0.85, 0.70, 1.03 per category increase) but imprecise estimates for sleep duration and insomnia symptoms. Two sample MR using data from BCAC supported findings for a protective effect of morning preference (inverse variance weighted odds ratio 0.88, 95% confidence interval 0.82 to 0.93 per category increase) and adverse effect of increased sleep duration (1.19, 1.02 to 1.39 per hour increase) on breast cancer risk (both oestrogen receptor positive and oestrogen receptor negative), whereas evidence for insomnia symptoms was inconsistent. Results were largely robust to sensitivity analyses accounting for horizontal pleiotropy.

conclusionsFindings showed consistent evidence for a protective effect of morning preference and suggestive evidence for an adverse effect of increased sleep duration on breast cancer risk.

Indexed as

SleepAdultAgedBreast NeoplasmsCase-Control StudiesCircadian RhythmComorbidityConfounding Factors, EpidemiologicFemaleGenome-Wide Association StudyHumansIncidenceMendelian Randomization AnalysisMiddle AgedMultivariate AnalysisProspective Studies

Identifiers

PMID31243001
PMCPMC6592406
OpenAlexW2953389908

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.