Evidence map›Paper›PMID 31242907›Full record

ArticleVirology journal2019

Diversity and distribution of type A influenza viruses: an updated panorama analysis based on protein sequences.

Qingye Zhuang, Suchun Wang, Shuo Liu, Guangyu Hou, Jinping Li, Wenming Jiang, Kaicheng Wang, Cheng Peng, Dong Liu, Aizhen Guo and 1 more

Open access · goldAbstract read
In one paragraph

Article in Virology journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 54 citations in OpenAlex.

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  7. Mechanistic insights into the small-molecule inhibition of influenza A virus entry.Proceedings of the National Academy of Sciences of the United States of America · 2025
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  8. Optimizing delivery in a multivalent subunit influenza vaccine using mixed polymeric microparticle degradation rates.Journal of controlled release : official journal of the Controlled Release Society · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Qingye ZhuangThe State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, 1 Shizishan Street, Wuhan, 430070, China.
Suchun WangNational Avian Influenza Professional Laboratory, China Animal Health and Epidemiology Center, 369 Nanjing Road, Qingdao, 266032, China.
Shuo LiuNational Avian Influenza Professional Laboratory, China Animal Health and Epidemiology Center, 369 Nanjing Road, Qingdao, 266032, China.
Guangyu HouNational Avian Influenza Professional Laboratory, China Animal Health and Epidemiology Center, 369 Nanjing Road, Qingdao, 266032, China.
Jinping LiNational Avian Influenza Professional Laboratory, China Animal Health and Epidemiology Center, 369 Nanjing Road, Qingdao, 266032, China.
Wenming JiangNational Avian Influenza Professional Laboratory, China Animal Health and Epidemiology Center, 369 Nanjing Road, Qingdao, 266032, China.
Kaicheng WangNational Avian Influenza Professional Laboratory, China Animal Health and Epidemiology Center, 369 Nanjing Road, Qingdao, 266032, China.
Cheng PengNational Avian Influenza Professional Laboratory, China Animal Health and Epidemiology Center, 369 Nanjing Road, Qingdao, 266032, China.
Dong LiuQingdao YeBio Bioengineering Co., Ltd, 369 Nanjing Road, Qingdao, 266032, China.
Aizhen GuoThe State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, 1 Shizishan Street, Wuhan, 430070, China. aizhen@mail.hzau.edu.cn.
Jiming ChenNational Avian Influenza Professional Laboratory, China Animal Health and Epidemiology Center, 369 Nanjing Road, Qingdao, 266032, China. jmchen678@qq.com.ORCID 0000-0002-0404-0830
China Animal Health and Epidemiology Center · CNHuazhong Agricultural University · CNYebio Bioengineering (China) · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundType A influenza viruses (IAVs) cause significant infections in humans and multiple species of animals including pigs, horses, birds, dogs and some marine animals. They are of complicated phylogenetic diversity and distribution, and analysis of their phylogenetic diversity and distribution from a panorama view has not been updated for multiple years.

methods139,872 protein sequences of IAVs from GenBank were selected, and they were aligned and phylogenetically analyzed using the software tool MEGA 7.0. Lineages and subordinate lineages were classified according to the topology of the phylogenetic trees and the host, temporal and spatial distribution of the viruses, and designated using a novel universal nomenclature system.

resultsLarge phylogenetic trees of the two external viral genes (HA and NA) and six internal genes (PB2, PB1, PA, NP, MP and NS) were constructed, and the diversity and the host, temporal and spatial distribution of these genes were calculated and statistically analyzed. Various features regarding the diversity and distribution of IAVs were confirmed, revised or added through this study, as compared with previous reports. Lineages and subordinate lineages were classified and designated for each of the genes based on the updated panorama views.

conclusionsThe panorama views of phylogenetic diversity and distribution of IAVs and their nomenclature system were updated and assumed to be of significance for studies and communication of IAVs.

Indexed as

Evolution, MolecularGenetic VariationPhylogenyAmino Acid SequenceAnimalsBirdsChiropteraDogsGenes, ViralHorsesHumansInfluenza A virusSwineDistributionDiversityInfluenza virusNomenclaturePhylogeneticsProtein

Identifiers

PMID31242907
PMCPMC6595669
OpenAlexW2955646128

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.