ArticleBMC infectious diseases2019
The etiology of acute meningitis and encephalitis syndromes in a sentinel pediatric hospital, Shenzhen, China.
Article in BMC infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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18 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Global patterns of antibiotic resistance in group BFrontiers in microbiology · 2025Pooled it
- Epidemiological trends and neurological outcomes of pediatric central nervous system infections in rural part of western India.World journal of clinical pediatrics · 2026Article
- Clinical epidemiology, determinants, and outcomes of severe viral encephalitis in Chinese children: a multicenter retrospective cohort study.BMC infectious diseases · 2026Article
- Clinical and laboratory profiles of acute central nervous system infections in a Chinese pediatric cohort: a five-year retrospective analysis.BMC pediatrics · 2026Article
- Detection of JC virus DNA in CSF of pediatric patients with non-PML neurological disorders.Virology journal · 2026Article
- Clinical and epidemiological characteristics of hospitalized children with enterovirus infection: a retrospective study from 2016 to 2025 at Beijing children's hospital.BMC infectious diseases · 2026Article
- Evaluation of children with acute central nervous system infections admitted to the pediatric intensive care unit and pediatric ward: a retrospective study.BMC pediatrics · 2024Article
- Immunity Dynamics ofVaccines · 2024Article
- The Prevalence of Enteroviruses, Mumps virus, and Herpes Simplex Virus-1 in Cerebrospinal Fluid Samples of Children with Aseptic Meningitis.Archives of Razi Institute · 2024Article
- Antimicrobial susceptibility profiles of invasive bacterial infections among children from low- and middle-income countries in the Western Pacific Region (WPRO) - a systematic review and meta-analysis.The Lancet regional health. Western Pacific · 2024Article
- Integrating DNA/RNA microbe detection and host response for accurate diagnosis, treatment and prognosis of childhood infectious meningitis and encephalitis.Journal of translational medicine · 2024Article
- Diagnostic status and epidemiological characteristics of community-acquired bacterial meningitis in children from 2019 to 2020: a multicenter retrospective study.BMC pediatrics · 2024Article
- Pathogen Distribution of Neonatal Bacterial Meningitis in the Era of Multidrug-Resistant Bacteria: A Single-Center Experience.Infection and drug resistance · 2024Article
- Pediatric central nervous system infections in the Amazon: clinical and laboratory profiles.Frontiers in public health · 2023Article
- Development of a multiplex droplet digital PCR assay for detection of enterovirus, parechovirus, herpes simplex virus 1 and 2 simultaneously for diagnosis of viral CNS infections.Virology journal · 2022Article
- ComplicatedMicroorganisms · 2021Article
- Epidemiology and Drug Resistance of Pathogens Isolated from Cerebrospinal Fluids at a Children's Medical Center in Eastern China During 2006-2020.Infection and drug resistance · 2021Article
- Etiology, Clinical Presentation and Incidence of Infectious Meningitis and Encephalitis in Polish Children.Journal of clinical medicine · 2020Article
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12 authors at 5 institutions in 1 country.
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Abstract
backgroundAcute meningitis and encephalitis syndromes (AMES) is a severe neurological infection which causes high case fatality and severe sequelae in children. To determine the etiology of childhood AMES in Shenzhen, a hospital-based study was undertaken.
methodsA total of 240 cerebrospinal fluid (CSF) samples from 171 children meeting the case definition were included and screened for 12 common causative organisms. The clinical data and conventional testing results were collected and analyzed. Whole genome sequencing was performed on a Neisseria meningitidis isolate.
resultsA pathogen was found in 85 (49.7%) cases; Group B Streptococcus (GBS) was detected in 17 cases, Escherichia coli in 15, Streptococcus pneumoniae in 14, enterovirus (EV) in 13, herpes simplex virus (HSV) in 3, N. meningitidis in 1, Haemophilus influenzae in 1, and others in 23. Notably, HSV was found after 43 days of treatment. Twelve GBS and 6 E. coli meningitis were found in neonates aged less than 1 month; 13 pneumococcal meningitis in children aged > 3 months; and 12 EV infections in children aged > 1 year old. The multilocus sequence typing of serogroup B N. meningitidis isolate was ST-3200/CC4821. High resistance rate to tetracycline (75%), penicillin (75%), and trimethoprim/sulfamethoxazole (75%) was found in 4 of S. pneumoniae isolates; clindamycin (100%) and tetracycline (100%) in 9 of GBS; and ampicillin (75%) and trimethoprim/sulfamethoxazole (67%) in 12 of E. coli.
conclusionsThe prevalence of N. meningitidis and JEV was very low and the cases of childhood AMES were mainly caused by other pathogens. GBS and E. coli were the main causative organisms in neonates, while S. pneumoniae and EV were mainly found in older children. HSV could be persistently found in the CSF samples despite of the treatment. A better prevention strategy for GBS, the introduction of pneumococcal vaccine, and incorporation of PCR methods were recommended.
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