Evidence map›Paper›PMID 31242814›Full record

SynthesisTechnology in cancer research & treatment2019

Association of Methylenetetrahydrofolate Reductase, Vitamin D Receptor, and Interleukin-16 Gene Polymorphisms With Renal Cell Carcinoma Risk.

Tianbiao Zhou, Hongyan Li, Wei-Ji Xie, Zhiqing Zhong, Hongzhen Zhong, Zhi-Jun Lin

Open access · goldAbstract readMeta-Analysis
In one paragraph

Synthesis in Technology in cancer research & treatment, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Vitamin D receptor gene polymorphisms and its interactions with environmental factors on renal cell carcinoma risk.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2021
    Article
  5. Association of functionalOncotarget · 2020
    Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Tianbiao Zhou1 Department of Nephrology, the Second Affiliated Hospital of Shantou University Medical College, Shantou, China.
Hongyan Li2 Department of Nephrology, Huadu District People's Hospital of Guangzhou, Southern Medical University, Guangzhou, China.
Wei-Ji Xie1 Department of Nephrology, the Second Affiliated Hospital of Shantou University Medical College, Shantou, China.
Zhiqing Zhong1 Department of Nephrology, the Second Affiliated Hospital of Shantou University Medical College, Shantou, China.
Hongzhen Zhong1 Department of Nephrology, the Second Affiliated Hospital of Shantou University Medical College, Shantou, China.
Zhi-Jun Lin1 Department of Nephrology, the Second Affiliated Hospital of Shantou University Medical College, Shantou, China.
Second Affiliated Hospital of Shantou University Medical College · CNShantou University · CNSouthern Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this meta-analysis, we investigated the association of methylenetetrahydrofolate reductase, vitamin D receptor, and interleukin-16 gene polymorphisms with the risk of renal cell carcinoma. We searched the PubMed and Cochrane Library databases up to July 1, 2017, and included 12 eligible case-control studies in our analysis. The vitamin D receptor ApaI A allele, ApaI AA and aa genotypes, BsmI B allele, and Fok1 FF genotype were all associated with the risk of renal cell carcinoma in Asian populations. However, methylenetetrahydrofolate reductase (rs1801133 and rs1801131), vitamin D receptor (TaqI and Fok1), and interleukin-16 (rs4778889 and rs11556218) gene polymorphisms were not associated with the risk of renal cell carcinoma. Our study indicates that the vitamin D receptor ApaI A allele, ApaI AA and aa genotypes, BsmI B allele, and Fok1 FF genotype are associated with renal cell carcinoma risk.

Indexed as

Carcinoma, Renal CellGenetic Predisposition to DiseaseInterleukin-16Kidney NeoplasmsMethylenetetrahydrofolate Reductase (NADPH2)Polymorphism, Single NucleotideReceptors, CalcitriolAllelesCase-Control StudiesGenetic Association StudiesGenotypeHumansOdds RatioRisk AssessmentRisk FactorsIl16 protein, humanInterleukin-16Methylenetetrahydrofolate Reductase (NADPH2)MTHFR protein, humanReceptors, CalcitriolVDR protein, humangene polymorphisminterleukin-16meta-analysismethylenetetrahydrofolate reductaserenal cell carcinomavitamin D receptor

Identifiers

PMID31242814
PMCPMC6598331
OpenAlexW2953818673

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.