Evidence map›Paper›PMID 31242766›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019

The nucleoside diphosphate kinase NDK-1/NME1 promotes phagocytosis in concert with DYN-1/Dynamin.

Zsolt Farkas, Metka Petric, Xianghua Liu, Floriane Herit, Éva Rajnavölgyi, Zsuzsa Szondy, Zsófia Budai, Tamás I Orbán, Sára Sándor, Anil Mehta and 9 more

Open access · greenAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Conserved and Distinct Elements of Phagocytosis in Human andInternational journal of molecular sciences · 2021
    Review
  3. Article
  4. NME/NM23/NDPK and Histidine Phosphorylation.International journal of molecular sciences · 2020
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 7 institutions in 4 countries.

Zsolt FarkasDepartment of Biological Anthropology, Eötvös Loránd University, Budapest, Hungary.
Metka PetricINSERM, Unité 1016, Institut Cochin, Paris, France.
Xianghua LiuVerna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA.
Floriane HeritINSERM, Unité 1016, Institut Cochin, Paris, France.
Éva RajnavölgyiDepartment of Immunology, University of Debrecen, Debrecen, Hungary.
Zsuzsa SzondyDepartment of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
Zsófia BudaiDepartment of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
Tamás I OrbánInstitute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary.
Sára SándorInstitute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary.
Anil MehtaDivision of Medical Sciences, Ninewells Hospital Medical School, Dundee, United Kingdom.
Zsuzsa BajtayDepartment of Immunology and MTA-ELTE Immunology Research Group, Eötvös Loránd University, Budapest, Hungary.
Tibor KovácsDepartment of Genetics, Eötvös Loránd University, Budapest, Hungary.
Sung Yun JungVerna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA.
Muhammed Afaq ShakirVerna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA.
Jun QinVerna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA.
Zheng ZhouVerna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA.
Florence NiedergangINSERM, Unité 1016, Institut Cochin, Paris, France.
Mathieu BoissanSorbonne Université, University Pierre and Marie Curie (UPMC) Paris 06, INSERM, Unité Mixte de Recherche (UMR) S938, Saint-Antoine Research Center, Paris, France; and.
Krisztina Takács-VellaiDepartment of Biological Anthropology, Eötvös Loránd University, Budapest, Hungary.
Baylor College of Medicine · USEötvös Loránd University · HUUniversity of Debrecen · HUDélégation Paris 5 · FRInstitute of Molecular Life Sciences · HUInserm · FRNinewells Hospital · GB

Funding

Recognition of Apoptotic Cells for Their PhagocytosisR01GM067848 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI ZHOU, ZHENG · 2003 to 2021
$5.7M
RECOGNITION OF APOPTOTIC AND NECROTIC CELLS BY THEIR PHAGOCYTESR01GM104279 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI ZHOU, ZHENG · 2014 to 2017
$1.2M
NIGMS NIH HHS R01 GM067848NIGMS NIH HHS R01 GM104279
6 · The paper itself

Abstract

Phagocytosis of various targets, such as apoptotic cells or opsonized pathogens, by macrophages is coordinated by a complex signaling network initiated by distinct phagocytic receptors. Despite the different initial signaling pathways, each pathway ends up regulating the actin cytoskeletal network, phagosome formation and closure, and phagosome maturation leading to degradation of the engulfed particle. Herein, we describe a new phagocytic function for the nucleoside diphosphate kinase 1 (NDK-1), the nematode counterpart of the first identified metastasis inhibitor NM23-H1 (nonmetastatic clone number 23) nonmetastatic clone number 23 or nonmetastatic isoform 1 (NME1). We reveal by coimmunoprecipitation, Duolink proximity ligation assay, and mass spectrometry that NDK-1/NME1 works in a complex with DYN-1/Dynamin (

Indexed as

ActinsAnimalsApoptosisCaenorhabditis elegansCaenorhabditis elegans ProteinsCells, CulturedDynaminsHumansLeukocytes, MononuclearMacrophagesMiceMice, Inbred C57BLNM23 Nucleoside Diphosphate KinasesPhagocytosisPhagosomesSignal TransductionActinsCaenorhabditis elegans ProteinsDyn-1 protein, C elegansDynaminsNM23 Nucleoside Diphosphate Kinasesactin cupapoptotic clearancemetastasis inhibitorphagosome formationphagosome maturation

Identifiers

PMID31242766
PMCPMC6819981
OpenAlexW2955399237

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.