Evidence map›Paper›PMID 31242720›Full record

ArticleInternational journal of stem cells2019

Immunosuppressive Effect of Exosomes from Mesenchymal Stromal Cells in Defined Medium on Experimental Colitis.

Zhi Jie Ma, Yun Hong Wang, Zhi Gang Li, Ying Wang, Bing Yao Li, Hui Yan Kang, Xiao Yun Wu

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of stem cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 65 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Zhi Jie MaDepartment of Pharmacy, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Yun Hong WangDepartment of Technology, Stem Cell Medicine Engineering & Technology Research Center of Inner Mongolia, Huhhot, Inner Mongolia, China.
Zhi Gang LiDepartment of Research and Development, Beijing Jingmeng Stem Cell Technology CO., LTD, Beijing, China.
Ying WangHealth Examination Center, Tongliao City Hospital, Tongliao, Inner Mongolia, China.
Bing Yao LiDepartment of Medicine, Chifeng Cancer Hospital, Chifeng, Inner Mongolia, China.
Hui Yan KangDepartment of Technology, Stem Cell Medicine Engineering & Technology Research Center of Inner Mongolia, Huhhot, Inner Mongolia, China.
Xiao Yun WuDepartment of Technology, Stem Cell Medicine Engineering & Technology Research Center of Inner Mongolia, Huhhot, Inner Mongolia, China.
Tongliao Academy of Agricultural Sciences · CNBeijing Friendship Hospital · CNChifeng Municipal Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesThe exosomes released by mesenchymal stromal cells (MSCs) in classical FBS-containing media have been demonstrated as an alternative, cell-free therapy in various diseases including inflammatory bowel disease (IBD). It has been found that the function of exosomes is affected by culture condition. We previously developed a serum-free, xeno-free and chemically defined medium, and umbilical cord-derived MSCs in this medium retained the immunosuppressive capability.

methodsIn this study, we evaluated the immunosuppressive function of exosomes from MSCs (MSC-Exo) in defined medium and their therapeutic effect on treating colitis. RESULTS AND

conclusionsIn vitro studies indicated that MSC-Exo reduced the concentration of pro-inflammatory cytokines IFN-

Indexed as

ColitisExosomeImmunosuppressive effectMesenchymal stromal cellsSerum free

Identifiers

PMID31242720
PMCPMC6881044
OpenAlexW2954803946

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.