Evidence map›Paper›PMID 31242689›Full record

ArticleMolecules (Basel, Switzerland)2019

Duodenoscope-Associated Infections beyond the Elevator Channel: Alternative Causes for Difficult Reprocessing.

Gheorghe G Balan, Irina Rosca, Elena-Laura Ursu, Adrian Fifere, Cristian-Dragos Varganici, Florica Doroftei, Ioana-Andreea Turin-Moleavin, Vasile Sandru, Gabriel Constantinescu, Daniel Timofte and 3 more

Registry-linked trialAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04628949 (A Single-Use Duodenoscope in a Real-World Setting), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04628949 nacompletednot on this mapstarted 2021, after this paper: background citation

A Single-Use Duodenoscope in a Real-World Setting

TypeinterventionalSponsorAmbu A/SRan2021 to 2022Enrolled248ConditionsEndoscopic Retrograde Cholangiopancreatography (ERCP)ArmsaScope™ Duodeno endoscope and aBox™ Duodeno
3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Gheorghe G BalanDepartment of Gastroenterology, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 16 University Street, 700115 Iași, Romania. balan.gheo@me.com.
Irina RoscaCentre of Advanced Research in Bionanoconjugates and Biopolymers (IntelCentru), ''Petru Poni'' Institute of Macromolecular Chemistry, 41A Grigore Ghica Vodă Alley, 700487 Iași, Romania. rosca.irina@icmpp.ro.ORCID 0000-0003-3080-1709
Elena-Laura UrsuCentre of Advanced Research in Bionanoconjugates and Biopolymers (IntelCentru), ''Petru Poni'' Institute of Macromolecular Chemistry, 41A Grigore Ghica Vodă Alley, 700487 Iași, Romania. ursu.laura@icmpp.ro.
Adrian FifereCentre of Advanced Research in Bionanoconjugates and Biopolymers (IntelCentru), ''Petru Poni'' Institute of Macromolecular Chemistry, 41A Grigore Ghica Vodă Alley, 700487 Iași, Romania. fifere@icmpp.ro.
Cristian-Dragos VarganiciCentre of Advanced Research in Bionanoconjugates and Biopolymers (IntelCentru), ''Petru Poni'' Institute of Macromolecular Chemistry, 41A Grigore Ghica Vodă Alley, 700487 Iași, Romania. varganici.cristian@icmpp.ro.ORCID 0000-0002-4813-9162
Florica DorofteiCentre of Advanced Research in Bionanoconjugates and Biopolymers (IntelCentru), ''Petru Poni'' Institute of Macromolecular Chemistry, 41A Grigore Ghica Vodă Alley, 700487 Iași, Romania. florica.doroftei@icmpp.ro.
Ioana-Andreea Turin-MoleavinCentre of Advanced Research in Bionanoconjugates and Biopolymers (IntelCentru), ''Petru Poni'' Institute of Macromolecular Chemistry, 41A Grigore Ghica Vodă Alley, 700487 Iași, Romania. moleavin.ioana@icmpp.ro.
Vasile SandruDepartment of Gastroenterology Research, Clinical Emergency Hospital of Bucharest, 8 Calea Floreasca, 014461 Bucharest, Romania. drsandruvasile@gmail.com.ORCID 0000-0001-6206-6126
Gabriel ConstantinescuDepartment of Gastroenterology Research, Clinical Emergency Hospital of Bucharest, 8 Calea Floreasca, 014461 Bucharest, Romania. gabrielconstantinescu63@gmail.com.
Daniel TimofteDepartment of Gastroenterology, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 16 University Street, 700115 Iași, Romania. dantimofte@yahoo.com.ORCID 0000-0002-6604-874X
Gabriela StefanescuDepartment of Gastroenterology, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 16 University Street, 700115 Iași, Romania. gabriela.stefanescu@gmail.com.
Anca TrifanDepartment of Gastroenterology, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 16 University Street, 700115 Iași, Romania. ancatrifan@yahoo.com.
Catalin Victor SfartiDepartment of Gastroenterology, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 16 University Street, 700115 Iași, Romania. cvsfarti@gmail.com.

Funding

European Union's Horizon 2020 No 667387 WIDESPREAD 2-2014 SupraChem LabRomanian Ministry of Research and Innovation, CCCDI - UEFISCDI PN-III-P1-1.2-PCCDI-2017-0697/13PCCDI/2018
6 · The paper itself

Abstract

objectivesDuodenoscopes have been widely used for both diagnostic and therapeutic endoscopic retrograde cholangiopancreatography (ERCP) procedures, but recently, numerous outbreaks of multidrug-resistant organisms (MDRO) infections have been reported which has led to extensive research for their possible causes. Consequently, the aim of this study is to search for possible duodenoscope surface damages that could provide an alternative and plausible source of infections. MATERIALS AND

methodsIn order to assess both outer and inner surfaces, a duodenoscope was dismantled and samples were taken from the outer resin polymer and from the air/water, elevator, and working (biopsy) channels that were characterized by FTIR, DSC, TGA, AFM, SEM techniques and the antimicrobial activity were tested.

resultsAlterations were noticed on both the coating and working channel polymers, with external alterations increasing progressively from the proximal sample to the distal sample near the tip of the scope. However, the results showed that the coating surface was still efficient against bacterial adhesion. Changes in surface texture and also morphological changes were shown.

conclusionsThe study describes the impact of routine procedural use and reprocessing cycles on the duodenoscope, showing that these may possibly make it susceptible to bacterial contamination and MDRO biofilm formation due to difficult reprocessing of the altered surfaces.

Indexed as

BiofilmsCalorimetry, Differential ScanningCholangiopancreatography, Endoscopic RetrogradeCross InfectionDisinfectionDuodenoscopesEnvironmental MicrobiologyEquipment ReuseHumansMicroscopy, Atomic ForceSpectroscopy, Fourier Transform InfraredThermogravimetrycarbapenem-resistant enterobacteriaceaeendoscopic retrograde cholangiopancreatographynosocomial infectionsreprocessing

Identifiers

PMID31242689
PMCPMC6631070

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.