Evidence map›Paper›PMID 31242622›Full record

ArticleMarine drugs2019

Rational Design of Alginate Lyase from

Min Yang, Su-Xiao Yang, Zhe-Min Liu, Nan-Nan Li, Li Li, Hai-Jin Mou

Abstract read
In one paragraph

Article in Marine drugs, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Sustainable Production ofFoods (Basel, Switzerland) · 2024
    Review
  6. Article
  7. Polymer degrading marineBeilstein journal of organic chemistry · 2024
    Review
  8. Article
  9. Acid-resistant enzymes: the acquisition strategies and applications.Applied microbiology and biotechnology · 2023
    Review
  10. Article
  11. Rational Design of Disulfide Bridges inMolecules (Basel, Switzerland) · 2023
    Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Enhanced Thermostability of D-Psicose 3-Epimerase fromInternational journal of molecular sciences · 2021
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Min YangCollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, China. minyang89@163.com.
Su-Xiao YangCollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, China. yangsuxiao66@163.com.
Zhe-Min LiuCollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, China. ocean2013@126.com.ORCID 0000-0002-5995-746X
Nan-Nan LiCollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, China. lxgcznlnn@163.com.
Li LiCollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, China. llcs0229@163.com.
Hai-Jin MouCollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, China. mousun@ouc.edu.cn.

Funding

Natural Science Foundation of Shandong Province ZR2017MD006Shandong Province Key Research and Development Project 2017YYSP003
6 · The paper itself

Abstract

Alginate lyase degrades alginate by the β-elimination mechanism to produce oligosaccharides with special bioactivities. The low thermal stability of alginate lyase limits its industrial application. In this study, introducing the disulfide bonds while using the rational design methodology enhanced the thermal stability of alginate lyase cAlyM from

Indexed as

AlginatesAlteromonadaceaeBacterial ProteinsCatalytic DomainEnzyme StabilityOligosaccharidesPolysaccharide-LyasesSubstrate SpecificityTemperatureAlginatesBacterial ProteinsOligosaccharidespoly(beta-D-mannuronate) lyasePolysaccharide-Lyasesalginate lyasedisulfide bondmolecular dynamic simulationrational designthermal stability

Identifiers

PMID31242622
PMCPMC6627800

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.