Evidence map›Paper›PMID 31242617›Full record

ArticleAntioxidants (Basel, Switzerland)2019

Evaluation of the Antioxidant Activity of

Guadalupe Firpo, María L Ramírez, Martín S Faillace, Maria Dos R Mendes de Brito, Ana P S Correia Lima E Silva, Jessica Pereira Costa, Marcela C Rodríguez, Gustavo A Argüello, Zsolt Szakonyi, Ferenc Fülöp and 1 more

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Differential Effect of 4Current medicinal chemistry · 2024
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Guadalupe FirpoINFIQC-CONICET. Departamento de Físicoquímica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, X5000HUA Córdoba, Argentina. gfirpo@fcq.unc.edu.ar.
María L RamírezINFIQC-CONICET. Departamento de Físicoquímica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, X5000HUA Córdoba, Argentina. mramirez@fcq.unc.edu.ar.
Martín S FaillaceINFIQC-CONICET. Departamento de Físicoquímica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, X5000HUA Córdoba, Argentina. mfaillace@unc.edu.ar.
Maria Dos R Mendes de BritoDepartment of Pharmaceutical Chemistry, Faculty of Facid Wyden, Federal University of Piauí, Teresina, PI. CEP 64.052-410, Brazil. mbrito@facid.edu.br.
Ana P S Correia Lima E SilvaDepartment of Pharmaceutical Chemistry, Faculty of Nursing, Federal University of Piauí, Teresina, PI. CEP 64.049-550, Brazil. apaulasantoslima@ufpi.edu.br.
Jessica Pereira CostaDepartment of Pharmaceutical Chemistry, Faculty of Facid Wyden, Federal University of Piauí, Teresina, PI. CEP 64.052-410, Brazil. jessicaprcosta@ufpi.edu.br.
Marcela C RodríguezINFIQC-CONICET. Departamento de Físicoquímica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, X5000HUA Córdoba, Argentina. marcela.rodriguez@fcq.unc.edu.ar.
Gustavo A ArgüelloDepartment of Pharmaceutical Chemistry, Faculty of Facid Wyden, Federal University of Piauí, Teresina, PI. CEP 64.052-410, Brazil. gaac@fcq.unc.edu.ar.
Zsolt SzakonyiInstitute of Pharmaceutical Chemistry, University of Szeged, H-6720 Szeged, Eötvös utca 6, Hungary. szakonyi@pharm.u-szeged.hu.ORCID 0000-0003-2432-8409
Ferenc FülöpInstitute of Pharmaceutical Chemistry, University of Szeged, H-6720 Szeged, Eötvös utca 6, Hungary. fulop@pharm.u-szeged.hu.ORCID 0000-0003-1066-5287
Walter J PeláezINFIQC-CONICET. Departamento de Físicoquímica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, X5000HUA Córdoba, Argentina. waldemar31@fcq.unc.edu.ar.

Funding

Consejo Nacional de Investigaciones Científicas y Técnicas PIP 11220170100423COConselho Nacional de Desenvolvimento Científico e Tecnológico CNPqCoordenação de Aperfeiçoamento de Pessoal de Nível Superior CAPESFondo para la Investigación Científica y Tecnológica PICT-2017-1555Secretaría de Ciencia y Tecnología SeCyT-Nº411/18
6 · The paper itself

Abstract

The growing interest in the chemistry of unsaturated ring-fused 1,3-heterocycles, in this particular case 1,3-oxazines, arise in part from their versatile pharmacological applications. In the present article, the evaluation of the in vitro and ex vivo antioxidant activity of two cyclohexene-fused oxazines is discussed. The in vitro antioxidant activity was evaluated by trapping the ABTS and hydroxyl radicals as well as the inhibition of the enzyme acetyl-cholinesterase and hemolysis of erythrocytes by 2,2'-Azobis(2-amidinopropane) dihydrochloride (AAPH). The results suggest that both unsaturated 1,3-oxazines are auspicious sources of biologically active compounds with good antioxidant properties. In addition, a comprehensive analysis of the interaction between these heterocycles with 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radicals, as well as the measurements of redox potential, provided evidence for a mechanism of antioxidant activity that takes place through electron transfer (ET) processes.

Indexed as

antioxidant activityantiradical powerET mechanismunsaturated-fused 1,3-oxazines

Identifiers

PMID31242617
PMCPMC6616633

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.