Evidence map›Paper›PMID 31242603›Full record

ReviewMolecules (Basel, Switzerland)2019

Macrocyclic Diterpenoids from Euphorbiaceae as A Source of Potent and Selective Inhibitors of Chikungunya Virus Replication.

Simon Remy, Marc Litaudon

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Bioactive Compounds fromPharmaceuticals (Basel, Switzerland) · 2021
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Simon RemyInstitut de Chimie des Substances Naturelles, CNRS ICSN, UPR 2301, Université Paris Saclay, 91198 Gif-sur-Yvette, France. simon.remy@cnrs.fr.ORCID 0000-0003-2247-6862
Marc LitaudonInstitut de Chimie des Substances Naturelles, CNRS ICSN, UPR 2301, Université Paris Saclay, 91198 Gif-sur-Yvette, France. marc.litaudon@cnrs.fr.ORCID 0000-0002-0877-8234
Centre National de la Recherche Scientifique · FR

Funding

Agence Nationale de la Recherche ANR- 10-LABX-25-01
6 · The paper itself

Abstract

Macrocyclic diterpenoids produced by plants of the Euphorbiaceae family are of considerable interest due to their high structural diversity; and their therapeutically relevant biological properties. Over the last decade many studies have reported the ability of macrocyclic diterpenoids to inhibit in cellulo the cytopathic effect induced by the chikungunya virus. This review; which covers the years 2011 to 2019; lists all macrocyclic diterpenoids that have been evaluated for their ability to inhibit viral replication. The structure-activity relationships and the probable involvement of protein kinase C in their mechanism of action are also detailed.

Indexed as

AnimalsAntiviral AgentsChikungunya FeverChikungunya virusDiterpenesEuphorbiaceaeHumansMolecular StructurePlant ExtractsStructure-Activity RelationshipVirus ReplicationAntiviral AgentsDiterpenesPlant ExtractschikungunyadaphnaneEuphorbiaceaeflexibilaneingenanejatrophanephorbolPKCpre-myrsinanetigliane

Identifiers

PMID31242603
PMCPMC6631467
OpenAlexW2955416637

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.