Evidence map›Paper›PMID 31242596›Full record

Trial reportNutrients2019

Mixed Spices at Culinary Doses Have Prebiotic Effects in Healthy Adults: A Pilot Study.

Qing-Yi Lu, Anna M Rasmussen, Jieping Yang, Ru-Po Lee, Jianjun Huang, Paul Shao, Catherine L Carpenter, Irene Gilbuena, Gail Thames, Susanne M Henning and 2 more

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 38 citations in OpenAlex.

  1. Trial
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  6. Article
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  9. Oxidative stress and food as medicine.Frontiers in nutrition · 2024
    Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Materials today. Bio · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Qing-Yi LuCenter for Human Nutrition, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA. qlu@mednet.ucla.edu.ORCID 0000-0002-1704-382X
Anna M RasmussenCenter for Human Nutrition, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA. ARasmussen@mednet.ucla.edu.ORCID 0000-0002-1030-7976
Jieping YangCenter for Human Nutrition, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA. JiepingYang@mednet.ucla.edu.
Ru-Po LeeCenter for Human Nutrition, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA. RuPoLee@mednet.ucla.edu.
Jianjun HuangCenter for Human Nutrition, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA. JianjunHuang@mednet.ucla.edu.
Paul ShaoCenter for Human Nutrition, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA. PShao@mednet.ucla.edu.
Catherine L CarpenterCenter for Human Nutrition, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA. CCarpenter@mednet.ucla.edu.
Irene GilbuenaCenter for Human Nutrition, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA. IGilbuena@mednet.ucla.edu.
Gail ThamesCenter for Human Nutrition, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA. GThames@mednet.ucla.edu.
Susanne M HenningCenter for Human Nutrition, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA. SHenning@mednet.ucla.edu.
David HeberCenter for Human Nutrition, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA. dheber@mednet.ucla.edu.
Zhaoping LiCenter for Human Nutrition, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA. zli@mednet.ucla.edu.ORCID 0000-0002-8662-4310
University of California, Los Angeles · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spices were used as food preservatives prior to the advent of refrigeration, suggesting the possibility of effects on microbiota. Previous studies have shown prebiotic activities in animals and in vitro, but there has not been a demonstration of prebiotic or postbiotic effects at culinary doses in humans. In this randomized placebo-controlled study, we determined in twenty-nine healthy adults the effects on the gut microbiota of the consumption daily of capsules containing 5 g of mixed spices at culinary doses by comparison to a matched control group consuming a maltodextrin placebo capsule. The 16S ribosomal RNA sequencing data were used for microbial characterization. Spice consumption resulted in a significant reduction in Firmicutes abundance (

Indexed as

CookingGastrointestinal MicrobiomeSpicesAdministration, OralAdolescentAdultAgedBacteriaCapsulesDouble-Blind MethodFecesFemaleHumansIntestinesLos AngelesMaleCapsulesPrebioticsdietary interventionfirmicutesgut microbiotaprebiotic effectshort-chain fatty acidsspices

Identifiers

PMID31242596
PMCPMC6627368
OpenAlexW2953789287

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.