Evidence map›Paper›PMID 31242583›Full record

ArticleInternational journal of molecular sciences2019

Serum Proteome Alterations in Human Cystathionine β-Synthase Deficiency and Ischemic Stroke Subtypes.

Marta Sikora, Izabela Lewandowska, Małgorzata Kupc, Jolanta Kubalska, Ałła Graban, Łukasz Marczak, Radosław Kaźmierski, Hieronim Jakubowski

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Anti-Alzheimer's & dementia (New York, N. Y.) · 2021
    Article
  6. The Antioxidant Role of One-Carbon Metabolism on Stroke.Antioxidants (Basel, Switzerland) · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Marta SikoraEuropean Centre for Bioinformatics and Genomics, Institute of Bioorganic Chemistry, Polish Academy of Sciences, 60-965 Poznań, Poland. martas@ibch.poznan.pl.
Izabela LewandowskaEuropean Centre for Bioinformatics and Genomics, Institute of Bioorganic Chemistry, Polish Academy of Sciences, 60-965 Poznań, Poland. izek1988@gmail.com.
Małgorzata KupcDepartment of Biochemistry and Biotechnology, University of Life Sciences, 60-632 Poznań, Poland. gosia.kupc@gmail.com.
Jolanta KubalskaDepartment of Genetics, Institute of Psychiatry and Neurology, 02-957 Warsaw, Poland. kubalska@ipin.edu.pl.
Ałła GrabanFirst Department of Neurology, Institute of Psychiatry and Neurology, 02-957 Warsaw, Poland. graban@ipin.edu.pl.
Łukasz MarczakEuropean Centre for Bioinformatics and Genomics, Institute of Bioorganic Chemistry, Polish Academy of Sciences, 60-965 Poznań, Poland. lukasmar@ibch.poznan.pl.
Radosław KaźmierskiDepartment of Neurology and Cerebrovascular Disorders, Poznań University of Medical Sciences, L. Bierkowski Hospital, 60-631 Poznań, Poland. rkazmierski@ump.edu.pl.ORCID 0000-0002-9760-4884
Hieronim JakubowskiDepartment of Biochemistry and Biotechnology, University of Life Sciences, 60-632 Poznań, Poland. jakubows@rutgers.edu.ORCID 0000-0001-5845-4409
Institute of Bioorganic Chemistry, Polish Academy of Sciences · PLInstitute of Psychiatry and Neurology · PLPoznan University of Medical Sciences · PLRutgers, The State University of New Jersey · USUniversity of Life Sciences in Poznań · PL

Funding

American Heart Association 17GRNT32910002Narodowe Centrum Nauki 2013/11/B/NZ1/00091Narodowe Centrum Nauki 2014/15/N/NZ5/01647Narodowe Centrum Nauki 2015/17/D/NZ5/03444Narodowe Centrum Nauki 2016/23/B/NZ5/00573Narodowe Centrum Nauki 2018/29/B/NZ4/0071
6 · The paper itself

Abstract

Ischemic stroke induces brain injury via thrombotic or embolic mechanisms involving large or small vessels. Cystathionine β-synthase deficiency (CBS), an inborn error of metabolism, is associated with vascular thromboembolism, the major cause of morbidity and mortality in affected patients. Because thromboembolism involves the brain vasculature in these patients, we hypothesize that CBS deficiency and ischemic stroke have similar molecular phenotypes. We used label-free mass spectrometry for quantification of changes in serum proteomes in CBS-deficient patients (

Indexed as

ProteomeProteomicsAdultBiomarkersBrain IschemiaComputational BiologyCystathionine beta-SynthaseFemaleHumansMaleMiddle AgedSignal TransductionStrokeBiomarkersCystathionine beta-SynthaseProteomecystathionine β-synthase deficiencyischemic stroke subtypeslabel-free mass spectrometryproteomicsproteostasisserum protein markers

Identifiers

PMID31242583
PMCPMC6627068
OpenAlexW2955202844

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.