ArticleDevelopmental biology2019
Morphogenesis of the kidney and lung requires branch-tip directed activity of the Adamts18 metalloprotease.
Article in Developmental biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- Current Advances in the Physiological Roles and Disease-Associated Mechanisms of ADAMTS16.International journal of molecular sciences · 2026Review
- Review
- The secreted protease ADAMTS18 is a novel activator of latent TGF-β to exacerbate renal fibrosis.Communications biology · 2025Article
- Ureter development and associated congenital anomalies.Nature reviews. Nephrology · 2025Review
- Expansion of genotypic and phenotypic findings inAmerican journal of ophthalmology case reports · 2025Article
- ADAMTS18 deficiency associates extracellular matrix dysfunction with a higher risk of HER2-positive mammary tumorigenesis and metastasis.Breast cancer research : BCR · 2024Article
- ADAMTS18Nature communications · 2022Article
- Comparative whole-genome transcriptome analysis in renal cell populations reveals high tissue specificity of MAPK/ERK targets in embryonic kidney.BMC biology · 2022Article
- The biomechanical basis of biased epithelial tube elongation in lung and kidney development.Development (Cambridge, England) · 2021Article
- Organ-Specific Branching Morphogenesis.Frontiers in cell and developmental biology · 2021Review
- Extracellular matrix dynamics in tubulogenesis.Cellular signalling · 2020Review
- Mutational analysis of genes with ureteric progenitor cell-specific expression in branching morphogenesis of the mouse kidney.Developmental dynamics : an official publication of the American Association of Anatomists · 2020Article
- The secreted protease Adamts18 links hormone action to activation of the mammary stem cell niche.Nature communications · 2020Article
- Genetic manipulation of ureteric bud tip progenitors in the mammalian kidney through an Adamts18 enhancer driven tet-on inducible system.Developmental biology · 2020Article
- Duplex kidney formation: developmental mechanisms and genetic predisposition.F1000Research · 2020Review
- Fgf10/Fgfr2b Signaling Orchestrates the Symphony of Molecular, Cellular, and Physical Processes Required for Harmonious Airway Branching Morphogenesis.Frontiers in cell and developmental biology · 2020Review
- Simple Rules Determine Distinct Patterns of Branching Morphogenesis.Cell systems · 2019Article
- Renal volume of five-year-old preterm children are not different than full-term controls.Jornal de pediatriaArticle
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Adamts18 encodes a secreted metalloprotease restricted to branch-tip progenitor pools directing the morphogenesis of multiple mammalian organs. Adamts18 was targeted to explore a potential role in branching morphogenesis. In the kidney, an arborized collecting system develops through extensive branching morphogenesis of an initial epithelial outgrowth of the mesonephric duct, the ureteric bud. Adamts18 mutants displayed a weakly penetrant phenotype: duplicated ureteric outgrowths forming enlarged, bi-lobed kidneys with an increased nephron endowment. In contrast, Adamts18 mutants showed a fully penetrant lung phenotype: epithelial growth was markedly reduced and early secondary branching scaled to the reduced length of the primary airways. Furthermore, there was a pronounced delay in the appearance of differentiated cell types in both proximal and distally positions of the developing airways. Adamts18 is closely related to Adamts16. In the kidney but not the lung, broad epithelial Adamts16 expression overlaps Adamts18 in branch tips. However, compound Adamts16/18 mutants displayed a comparable low penetrance duplicated ureteric phenotype, ruling out a possible role for Adamts16 as a functional modifier of the Adamts18 kidney phenotype. Given the predicted action of secreted Adamts18 metalloprotease, and broad expression of Adamts18 in branching organ systems, these findings suggest distinct requirements for matrix modelling in the morphogenesis of epithelial networks.
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