ArticleBosnian journal of basic medical sciences2020
Interleukins and inflammatory markers are useful in predicting the severity of acute pancreatitis.
Article in Bosnian journal of basic medical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Relationship of computed tomography quantified visceral adiposity with the severity and complications of acute pancreatitis: a systematic review.Japanese journal of radiology · 2023Pooled it
- Assessment of the course of acute pancreatitis in the light of aetiology: a systematic review and meta-analysis.Scientific reports · 2020Pooled it
- Tumor necrosis factor-α promotes abnormal glucose metabolism after acute pancreatitis by inducing islet β-cell apoptosisWorld journal of gastroenterology · 2025Article
- Comprehensive statistical analysis of serum interleukin-6 and C-reactive protein for early diagnosis of severe acute pancreatitis: A systematic review and meta-analysis.Journal of family medicine and primary care · 2025Article
- Role of Interleukin 6 in Acute Pancreatitis: A Possible Marker for Disease Prognosis.International journal of molecular sciences · 2024Review
- The relationship between inflammatory cytokines and in-hospital complications of acute pancreatitis.Immunity, inflammation and disease · 2024Article
- Identification and analysis of chemokine-related and NETosis-related genes in acute pancreatitis to develop a predictive model.Frontiers in genetics · 2024Article
- Establishment and Validation of a Dynamic Nomogram for Persistent Organ Failure in Acute Biliary Pancreatitis: A Retrospective Study.Journal of inflammation research · 2024Article
- Mitochondrial DNA Copy Number, a Damage-Associated Molecular Pattern Molecule, Can Predict Pancreatic Necrosis and Is Correlated with the Severity of Acute Pancreatitis.Digestive diseases and sciences · 2023Article
- Establishment and Validation of a Nomogram Prediction Model for the Severe Acute Pancreatitis.Journal of inflammation research · 2023Article
- MyD88 deficiency aggravates the severity of acute pancreatitis by promoting MyD88-independent TRIF pathway-mediated necrosis.Annals of translational medicine · 2022Article
- Development and validation of a prediction model for moderately severe and severe acute pancreatitis in pregnancy.World journal of gastroenterology · 2022Article
- Association of Genetic Variants inGenes · 2022Article
- Fire in the belly: A scoping review of the immunopathological mechanisms of acute pancreatitis.Frontiers in immunology · 2022Article
- Development an Inflammation-Related Factor-Based Model for Predicting Organ Failure in Acute Pancreatitis: A Retrospective Cohort Study.Mediators of inflammation · 2021Article
- Assessment of acute pancreatitis severity via determination of serum levels of hsa-miR-126-5p and IL-6.Experimental and therapeutic medicine · 2021Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute pancreatitis (AP) is a disease with significant morbidity and mortality. The aim of this study was to evaluate the predictive role of inflammatory markers, particularly interleukins (ILs), in the course of AP and to determine the frequency of etiologic factors of AP. We included patients with AP who were treated at our institution from May 1, 2012 to January 31, 2015. Different laboratory parameters, including ILs, and the severity scoring systems Ranson's criteria and Bedside Index of Severity in Acute Pancreatitis (BISAP) were analyzed. AP was classified into mild and severe, and independent parameters were compared between these groups. The predictive performance of each parameter was evaluated using receiver operating characteristic (ROC) curves and the area under the ROC curve (AUC). A binomial logistic regression was performed to evaluate Ranson's criteria and IL6, IL8, and IL10 (at admission and after 48 hours) in the course of AP. Overall, 96 patients were treated, 59 (61.5%) males and 37 (38.5%) females, average age 62.5 ± 16.8 years (range 22-91 years). The best predictor for the severity of AP was IL6, measured 48 hours after admission (AUC = 0.84). Other useful predictors of the severity of AP were lactate dehydrogenase (p < 0.001), serum glucose (p < 0.006), and difference in the platelet count (p < 0.001) between admission and after 48 hours (p < 0.001), hemoglobin (p < 0.027) and erythrocytes (p < 0.029). The major causes of AP were gallstones and alcohol consumption. According to our results, IL6 and Ranson score are important predictors of the severity of AP.
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