Evidence map›Paper›PMID 31242392›Full record

ArticleAmerican journal of respiratory cell and molecular biology2020

Airway Surface Liquid Has Innate Antiviral Activity That Is Reduced in Cystic Fibrosis.

Abigail R Berkebile, Jennifer A Bartlett, Mahmoud Abou Alaiwa, Steven M Varga, Ultan F Power, Paul B McCray

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 32 citations in OpenAlex.

  1. Antiviral defenses are diminished at birth in cystic fibrosis pig airways.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2026
    Article
  2. Review
  3. Article
  4. Viral airway injury promotes cell engraftment in an in vitro model of cystic fibrosis cell therapy.American journal of physiology. Lung cellular and molecular physiology · 2024
    Article
  5. Review
  6. Review
  7. Article
  8. Cellular and molecular architecture of submucosal glands in wild-type and cystic fibrosis pigs.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  9. Update in Pediatrics 2020.American journal of respiratory and critical care medicine · 2021
    Article
  10. Article
  11. Review
  12. Airway Surface Liquid and Impaired Antiviral Defense in Cystic Fibrosis.American journal of respiratory cell and molecular biology · 2020
    Article
  13. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Abigail R BerkebileDepartment of Microbiology and Immunology.
Jennifer A BartlettDepartment of Pediatrics.
Mahmoud Abou AlaiwaDepartment of Internal Medicine, and.
Steven M VargaDepartment of Microbiology and Immunology.
Ultan F PowerWellcome Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, Northern Ireland, United Kingdom.
Paul B McCrayDepartment of Microbiology and Immunology.
University of Iowa · USQueen's University Belfast · GB

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Christopher K Laubenthal · 2000 to 2026
$70.0M
Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5M
Vector CoreP01HL051670 · NHLBI · UNIVERSITY OF IOWA · PI MCCRAY, PAUL B · 1993 to 2019
$36.5M
Respiratory virus infection in early cystic fibrosis lung diseaseP01HL091842 · NHLBI · UNIVERSITY OF IOWA · PI ZABNER, JOSEPH · 2008 to 2022
$34.2M
Vector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Amy Leanne Ryan · 1998 to 2026
$30.5M
NCI NIH HHS P30 CA086862NHLBI NIH HHS P01 HL051670NHLBI NIH HHS P01 HL091842NIDDK NIH HHS P30 DK054759NIEHS NIH HHS P30 ES005605
6 · The paper itself

Abstract

Although chronic bacterial infections and inflammation are associated with progressive lung disease in patients with cystic fibrosis (CF), much less is known regarding the contributions of respiratory viral infections to this process. Clinical studies suggest that antiviral host defenses may be compromised in individuals with CF, and CF airway epithelia exhibit impaired antiviral responses

Indexed as

AnimalsAntiviral AgentsBody FluidsCystic FibrosisHydrogen-Ion ConcentrationImmunity, InnateLungRespiratory MucosaSwineTracheaVirus DiseasesVirusesAntiviral Agentsairway secretionsairway surface liquidantiviral proteinscystic fibrosishost defense

Identifiers

PMID31242392
PMCPMC6938132
OpenAlexW2954413677

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.