ArticlePLoS computational biology2019
Energetic costs of cellular and therapeutic control of stochastic mitochondrial DNA populations.
Article in PLoS computational biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Mitochondrial dynamics resolve physical-social tensions and challenges through adaptable multi-objective optimisation.bioRxiv : the preprint server for biology · 2026Article
- Structural diversity and evolutionary constraints of oxidative phosphorylation.Cell genomics · 2025Article
- Mitochondrial DNA editing: Key to the treatment of neurodegenerative diseases.Genes & diseases · 2025Review
- Metabolic rewiring caused by mitochondrial dysfunction promotes mTORC1-dependent skeletal aging.Science advances · 2025Article
- Evolution and maintenance of mtDNA gene content across eukaryotes.The Biochemical journal · 2024Review
- Cellular allostatic load is linked to increased energy expenditure and accelerated biological aging.Psychoneuroendocrinology · 2023Article
- Avoiding misleading estimates using mtDNA heteroplasmy statistics to study bottleneck size and selection.G3 (Bethesda, Md.) · 2023Article
- Cellular and environmental dynamics influence species-specific extents of organelle gene retention.Proceedings. Biological sciences · 2023Article
- OxPhos defects cause hypermetabolism and reduce lifespan in cells and in patients with mitochondrial diseases.Communications biology · 2023Article
- Stochastic survival of the densest and mitochondrial DNA clonal expansion in aging.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Mitochondrial DNA Heteroplasmy as an Informational Reservoir Dynamically Linked to Metabolic and Immunological Processes Associated with COVID-19 Neurological Disorders.Cellular and molecular neurobiology · 2022Review
- Organelle bottlenecks facilitate evolvability by traversing heteroplasmic fitness valleys.Frontiers in genetics · 2022Article
- Nuclear genome-wide associations with mitochondrial heteroplasmy.Science advances · 2021Article
- The social nature of mitochondria: Implications for human health.Neuroscience and biobehavioral reviews · 2021Review
- Cell identity and nucleo-mitochondrial genetic context modulate OXPHOS performance and determine somatic heteroplasmy dynamics.Science advances · 2020Article
- Evolving mtDNA populations within cells.Biochemical Society transactions · 2019Review
- Mitochondrial Network State Scales mtDNA Genetic DynamicsGenetics · 2019Article
- Varied Mechanisms and Models for the Varying Mitochondrial Bottleneck.Frontiers in cell and developmental biology · 2019Article
- Large-scale genetic analysis reveals mammalian mtDNA heteroplasmy dynamics and variance increase through lifetimes and generations.Nature communications · 2018Article
- Mitochondrial Heterogeneity.Frontiers in genetics · 2018Review
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Authors and funding
6 authors.
Funding
Abstract
The dynamics of the cellular proportion of mutant mtDNA molecules is crucial for mitochondrial diseases. Cellular populations of mitochondria are under homeostatic control, but the details of the control mechanisms involved remain elusive. Here, we use stochastic modelling to derive general results for the impact of cellular control on mtDNA populations, the cost to the cell of different mtDNA states, and the optimisation of therapeutic control of mtDNA populations. This formalism yields a wealth of biological results, including that an increasing mtDNA variance can increase the energetic cost of maintaining a tissue, that intermediate levels of heteroplasmy can be more detrimental than homoplasmy even for a dysfunctional mutant, that heteroplasmy distribution (not mean alone) is crucial for the success of gene therapies, and that long-term rather than short intense gene therapies are more likely to beneficially impact mtDNA populations.
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