ArticleJournal of acquired immune deficiency syndromes (1999)2019
Risk Factors for Falls, Falls With Injury, and Falls With Fracture Among Older Men With or at Risk of HIV Infection.
Article in Journal of acquired immune deficiency syndromes (1999), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Developing an HIV-specific falls risk prediction model with a novel clinical index: a systematic review and meta-analysis method.BMC infectious diseases · 2024Pooled it
- HIV Neuropathy-a Review of Mechanisms, Diagnosis, and Treatment of Pain.Current pain and headache reports · 2021Pooled it
- A Fall Prevention Feasibility Trial for People With HIV and Alcohol Use.OTJR : occupation, participation and health · 2025Trial
- Higher iron stores and the HFE 187C>G variant delay onset of peripheral neuropathy during combination antiretroviral therapy.PloS one · 2020Trial
- Prevalence and clinical correlates of frailty among adults with HIV infection and unhealthy alcohol or drug use.AIDS (London, England) · 2026Article
- Association of Cannabis Use With Risk of Subsequent Falls Among Adults Aging With HIV.Open forum infectious diseases · 2026Article
- Cardiovascular Disease Risk and Falls in Men and Women Living With and Without HIV in MACS/WIHS Combined Cohort Study.Journal of acquired immune deficiency syndromes (1999) · 2026Article
- Modeled Health and Economic Burden of Frailty and Falls Among Adults With HIV.JAMA network open · 2026Article
- Alcohol use disorder, but not current alcohol use is associated with falls among people with HIV in care.AIDS (London, England) · 2025Article
- Postural Stability as a Measure of Fall Risk in Older People with and without HIV.AIDS research and human retroviruses · 2025Observational
- Antiretroviral drug use and the risk of falls in people living with HIV: a systematic review and meta-analysis.Annals of medicine and surgery (2012) · 2023Review
- HIV and an Ageing Population-What Are the Medical, Psychosocial, and Palliative Care Challenges in Healthcare Provisions.Microorganisms · 2023Review
- Assessing the contributions of modifiable risk factors to serious falls and fragility fractures among older persons living with HIV.Journal of the American Geriatrics Society · 2023Article
- Factors affecting quality of life in adults with HIV: A local cross-sectional study.The South African journal of physiotherapy · 2023Article
- HIV-Associated Conditions in Older Adults.Cureus · 2022Review
- Alcohol and falls among people with HIV infection: A view from Russia and the United States.Alcoholism, clinical and experimental research · 2022Article
- Regional Differences in Risk of Recurrent Falls Among Older U.S. Women and Men with HIV in the HIV Infection, Aging, and Immune Function Long-Term Observational Study.AIDS research and human retroviruses · 2022Observational
- Geriatric conditions and healthcare utilisation in older adults living with HIV.Age and ageing · 2022Article
- Low Quality of Life, Falls, and Pre-Frailty are Associated with Depressive Symptoms in Virologically Suppressed PLWHIV in Salvador, Brazil.AIDS and behavior · 2022Article
- Study Protocol for a Pilot Randomized Trial of a Virtual Occupational Therapy Fall Prevention Intervention for People With HIV and Alcohol Use.Substance abuse : research and treatment · 2022Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundFalls and fall risk factors are common among people living with HIV (PLWH). We sought to identify fall risk factors among men with and without HIV.
methodsMen aged 50-75 years with (n = 279) and without HIV (n = 379) from the Bone Strength Substudy of the Multicenter AIDS Cohort Study were included. Multinomial logistic regression models identified risk factors associated with falling.
resultsOne hundred fourteen (41%) PLWH and 149 (39%) of uninfected men had ≥1 fall; 54 (20%) PLWH and 66 (17%) of uninfected men experienced ≥2 falls over 2 years. Five and 3% of PLWH and uninfected men, respectively, had a fall-related fracture (P = 0.34). In multivariate models, the odds of ≥2 falls were greater among men reporting illicit drug use, taking diabetes or depression medications, and with peripheral neuropathy; obesity was associated with a lower risk (all P < 0.05). In models restricted to PLWH, detectable plasma HIV-1 RNA, current use of efavirenz or diabetes medications, illicit drug use, and peripheral neuropathy were associated with greater odds of having ≥2 falls (P < 0.05). Current efavirenz use was associated with increased odds of an injurious fall; longer duration of antiretroviral therapy was protective (both P < 0.05). Greater physical activity was associated with lower risk of falls with fracture (P < 0.05).
conclusionsIdentified risk factors for recurrent falls or fall with fracture included low physical activity, detectable HIV-1 RNA, use of efavirenz, or use of medications to treat diabetes and depression. Fall risk reduction should prioritize interventions targeting modifiable risk factors including increased physical activity, antiretroviral therapy adherence, and transition off efavirenz.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.