Evidence map›Paper›PMID 31242141›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2019

Incidence of AIDS-Related Kaposi Sarcoma in All 50 United States From 2000 to 2014.

Donna L White, Abiodun Oluyomi, Kathryn Royse, Yongquan Dong, Harrison Nguyen, Elaine Chang, Peter Richardson, Li Jiao, Jose M Garcia, Jennifer R Kramer and 2 more

Abstract read
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Skin Cancer in People of Color: A Systematic Review.American journal of clinical dermatology · 2022
    Pooled it
  2. Clinical Predictors and Incidence of Kaposi Sarcoma Among Males With HIV in the Treat-All Era in the United States and Canada.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Cancer Immunotherapy Trials Network 12: Pembrolizumab in HIV-Associated Kaposi Sarcoma.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Oncologic Treatment of HIV-Associated Kaposi Sarcoma 40 Years on.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2022
    Review
  14. Article
  15. Kaposi Sarcoma Rates Among Persons Living With Human Immunodeficiency Virus in the United States: 2008-2016.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
    Article
  16. Kaposi Sarcoma Incidence, Burden, and Prevalence in United States People with HIV, 2000-2015.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021
    Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Donna L WhiteSection of Gastroenterology and Hepatology, Department of Medicine, Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX.
Abiodun OluyomiDan L. Duncan Cancer Center at Baylor College of Medicine, Houston, TX.
Kathryn RoyseClinical Epidemiology and Comparative Effectiveness Program, Department of Medicine, VA Health Services Research Center of Innovations (IQuESt), Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX.
Yongquan DongClinical Epidemiology and Comparative Effectiveness Program, Department of Medicine, VA Health Services Research Center of Innovations (IQuESt), Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX.
Harrison NguyenClinical Epidemiology and Comparative Effectiveness Program, Department of Medicine, VA Health Services Research Center of Innovations (IQuESt), Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX.
Elaine ChangClinical Epidemiology and Comparative Effectiveness Program, Department of Medicine, VA Health Services Research Center of Innovations (IQuESt), Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX.
Peter RichardsonClinical Epidemiology and Comparative Effectiveness Program, Department of Medicine, VA Health Services Research Center of Innovations (IQuESt), Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX.
Li JiaoSection of Gastroenterology and Hepatology, Department of Medicine, Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX.
Jose M GarciaDepartment of Medicine, Geriatric Research, Education and Clinical Center (GRECC), VA Puget Sound Health Care System, Seattle, WA.
Jennifer R KramerClinical Epidemiology and Comparative Effectiveness Program, Department of Medicine, VA Health Services Research Center of Innovations (IQuESt), Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX.
Aaron P ThriftDan L. Duncan Cancer Center at Baylor College of Medicine, Houston, TX.
Elizabeth ChiaoClinical Epidemiology and Comparative Effectiveness Program, Department of Medicine, VA Health Services Research Center of Innovations (IQuESt), Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX.

Funding

Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Latesha Ellen Elopre · 1988 to 2026
$84.1M
Tumor Biology and Microenvironment (Program 1)P30CA022453 · NCI · WAYNE STATE UNIVERSITY · PI Julie Lynn Boerner · 1985 to 2026
$68.4M
(PQ3) Identifying Novel Pharmacologic Risk factors for Common Non-AIDS Defining Cancers in Individuals with Well-controlled HIV InfectionR01CA206476 · NCI · BAYLOR COLLEGE OF MEDICINE · PI KRAMER, JENNIFER R · 2016 to 2019
$3.0M
Advanced Glycation End-Products and Risk of Pancreatic CancerR01CA172880 · NCI · BAYLOR COLLEGE OF MEDICINE · PI JIAO, LI · 2013 to 2015
$1.6M
BCM Oncology Scholars Training ProgramT32CA174647 · NCI · BAYLOR COLLEGE OF MEDICINE · PI LIN, WEEI-CHIN · 2014 to 2018
$1.2M
The role of ghrelin and the ghrelin receptor GHSR1a in sarcopenia of agingR03AG040583 · NIA · BAYLOR COLLEGE OF MEDICINE · PI GARCIA, JOSE M. · 2011 to 2012
$157k
Sex hormones and HCV-related liver disease progressionI01CX001430 · VA · MICHAEL E DEBAKEY VA MEDICAL CENTER · PI WHITE, DONNA LORRAINE · 2017 to 2021
–
BLRD VA I01 BX000507CSRD VA I01 CX000174CSRD VA I01 CX001430NCI NIH HHS P30 CA022453NCI NIH HHS R01 CA172880NCI NIH HHS R01 CA206476NCI NIH HHS T32 CA174647NIAID NIH HHS P30 AI027767NIA NIH HHS R03 AG040583
6 · The paper itself

Abstract

backgroundAlthough declining rates of incident AIDS-related Kaposi sarcoma (KS) have been reported, KS incidence rates have noted race/ethnic, age, and geographic diversity. We performed a comprehensive assessment of recent secular trends in AIDS-related KS incidence in the United States.

methodsWe identified incident KS diagnosed in men aged 20-54 years (who comprise most AIDS-related KS in the United States) using the US Cancer Statistics registry data. Joinpoint analysis assessed for trends in age-adjusted incidence rates between 2000 and 2014 calculating average annual percentage changes (AAPCs) with 95% confidence intervals. Heat maps were generated to compare age-adjusted HIV incidence rates with KS incidence rates.

resultsAge-adjusted KS incidence rates nationwide decreased from 1.44/100,000 to 0.95/100,000 between 2000 and 2014. Observed rate changes varied across subgroups; eg, there were significant decreases in 30-44 years (AAPC = -5.4%), particularly in Whites and Blacks, significant increases among 20-29 years (AAPC = 2.7), primarily in Blacks, and stable rates among 45-54 years (AAPC = -0.03). In Southern United States, the incidence rates among Blacks did not significantly change. The states with highest average age-adjusted rates over the study period were Georgia (2.71/100,000), New York (2.16/100,000), California (2.02/100,000), Florida (1.90/100,000), and Texas (1.39/100,000), with significantly decreasing trends over time, except Georgia where rates increased (AAPC = 1.8).

conclusionsAlthough KS incidence rates have decreased nationally, age, racial, and geographic disparities persist, including increasing risk among younger Black men and particularly elevated rates in some southern states and urban areas. Further research is needed to address racial and geographic AIDS-related KS disparities.

Indexed as

AdultAge FactorsAIDS-Related Opportunistic InfectionsEthnicityFemaleGeographyHIV InfectionsHumansIncidenceMaleMiddle AgedRace FactorsRegistriesSarcoma, KaposiSex FactorsUnited States

Identifiers

PMID31242141
PMCPMC9400914

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.