Evidence map›Paper›PMID 31241996›Full record

ArticleAmerican journal of physiology. Renal physiology2019

Renal T cell infiltration occurs despite attenuation of development of hypertension with hydralazine in Envigo's female Dahl rat maintained on a low-Na

Amrita V Pai, Crystal A West, Aline M Arlindo de Souza, Parnika S Kadam, Emma J Pollner, David A West, Jia Li, Hong Ji, Xie Wu, Michelle J Zhu and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Renal physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. T cell-derived extracellular vesicles are elevated in essential HTN.American journal of physiology. Renal physiology · 2020
    Article
  4. Article
  5. Letter to the Editor: Importance of B cells in response to placental ischemia.American journal of physiology. Heart and circulatory physiology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Amrita V PaiDepartment of Biochemistry and Molecular and Cellular Biology, Georgetown University, Washington, District of Columbia.
Crystal A WestDepartment of Medicine, Georgetown University, Washington, District of Columbia.
Aline M Arlindo de SouzaDepartment of Medicine, Georgetown University, Washington, District of Columbia.ORCID 0000-0002-7031-2523
Parnika S KadamDepartment of Biochemistry and Molecular and Cellular Biology, Georgetown University, Washington, District of Columbia.
Emma J PollnerDepartment of Medicine, Georgetown University, Washington, District of Columbia.
David A WestDepartment of Medicine, Georgetown University, Washington, District of Columbia.
Jia LiDepartment of Medicine, Georgetown University, Washington, District of Columbia.
Hong JiDepartment of Medicine, Georgetown University, Washington, District of Columbia.
Xie WuDepartment of Medicine, Georgetown University, Washington, District of Columbia.
Michelle J ZhuDepartment of Medicine, Georgetown University, Washington, District of Columbia.
Chris BaylisDepartment of Physiology and Functional Genomics, University of Florida, Gainesville, Florida.
Kathryn SandbergDepartment of Biochemistry and Molecular and Cellular Biology, Georgetown University, Washington, District of Columbia.
Georgetown University · USUniversity of Florida · US

Funding

Maternal Morbidity and Mortality: Risk Factors, Early Detection and Personalized InterventionUL1TR001409 · NCATS · GEORGETOWN UNIVERSITY · PI GONDRE-LEWIS, MARJORIE C, MELLMAN, THOMAS A · 2015 to 2024
$37.8M
Translational Biomedical Science Training GrantTL1TR001431 · NCATS · GEORGETOWN UNIVERSITY · PI LEE, DEXTER L, SANDBERG, KATHRYN L · 2015 to 2024
$4.8M
Immune Modulation of HypertensionR01HL119380 · NHLBI · GEORGETOWN UNIVERSITY · PI SANDBERG, KATHRYN L · 2015 to 2018
$2.4M
Targeting angiotensin II in cognitive impairment associated with ovarian hormone lossR21AG060730 · NIA · GEORGETOWN UNIVERSITY · PI SANDBERG, KATHRYN L · 2018 to 2019
$430k
NCATS NIH HHS TL1 TR001431NCATS NIH HHS UL1 TR001409NHLBI NIH HHS R01 HL119380NIA NIH HHS R21 AG060730
6 · The paper itself

Abstract

Many studies have suggested that renal T cell infiltration contributes to the pathogenesis of salt-sensitive hypertension. To investigate this mechanism further, we determined T cell profiles in the kidney and lymphoid tissues as a function of blood pressure in the female Envigo Dahl salt-sensitive (SS) rat maintained on low-Na

Indexed as

Arterial PressureDiet, Sodium-RestrictedAnimalsAntihypertensive AgentsDisease Models, AnimalFemaleHeart RateHydralazineHypertensionKidneyLymph NodesRats, Inbred DahlSpleenT-Lymphocytes, Helper-InducerT-Lymphocytes, RegulatoryVasodilator AgentsAntihypertensive AgentsHydralazineVasodilator Agentsactivated T cellsCD25immune system

Identifiers

PMID31241996
PMCPMC6766632
OpenAlexW2954985069

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.