Evidence map›Paper›PMID 31241994›Full record

ArticleAmerican journal of physiology. Renal physiology2019

Smooth muscle-specific deletion of MnSOD exacerbates diabetes-induced bladder dysfunction in mice.

Rania A Elrashidy, Michael Kavran, Mervat E Asker, Hoda E Mohamed, Firouz Daneshgari, Guiming Liu

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Therapeutic Potential of Mitochondrial Transplantation with Focus on DBD.International journal of molecular sciences · 2026
    Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Insights into Manganese Superoxide Dismutase and Human Diseases.International journal of molecular sciences · 2022
    Review
  8. Review
  9. Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Rania A ElrashidyDepartment of Surgery, MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio.
Michael KavranDepartment of Radiology, Case Western Reserve University, Cleveland, Ohio.
Mervat E AskerDepartment of Biochemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
Hoda E MohamedDepartment of Biochemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
Firouz DaneshgariDepartment of Surgery, MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio.
Guiming LiuDepartment of Surgery, MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio.ORCID 0000-0002-9292-6198
Zagazig University · EGMetroHealth Medical Center · USCase Western Reserve University · US

Funding

Phenotrypes and Mechanisms of Urinary Incontinence in Obesity/pre-Type 2 DiabetesR01DK110567 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI DANESHGARI, FIROUZ, LIU, GUIMING · 2016 to 2020
$1.8M
Mechanism of Type I and II Caused Diabetic Bladder DysfunctionR01DK083733 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI DANESHGARI, FIROUZ · 2012 to 2015
$1.4M
NIDDK NIH HHS R01 DK083733NIDDK NIH HHS R01 DK110567
6 · The paper itself

Abstract

Bladder dysfunction in diabetes progresses gradually over time. However, the mechanisms of the development are not clear. We tested the hypothesis that oxidative stress plays a key role in the development of diabetic bladder dysfunction using an inducible smooth muscle (SM)-specific superoxide dismutase 2 (

Indexed as

Animalsbcl-2-Associated X ProteinBody WeightCaspase 3Diabetes Mellitus, ExperimentalMaleMiceMice, Inbred C57BLMice, KnockoutMuscle, SmoothOrgan SizeOxidative StressProto-Oncogene Proteins c-bcl-2Superoxide DismutaseSuperoxide Dismutase 2Tyrosine3-nitrotyrosineBax protein, mousebcl-2-Associated X ProteinBcl2 protein, mouseCasp3 protein, mouseCaspase 3Proto-Oncogene Proteins c-bcl-2Superoxide DismutaseSuperoxide Dismutase 2Tyrosinebladderdiabetesmanganese superoxide dismutase

Identifiers

PMID31241994
PMCPMC6843036
OpenAlexW2953939232

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.