Evidence map›Paper›PMID 31241993›Full record

ArticleAmerican journal of physiology. Renal physiology2019

Monophosphoryl lipid A induces protection against LPS in medullary thick ascending limb through induction of Tollip and negative regulation of IRAK-1.

Bruns A Watts, Esther Tamayo, Edward R Sherwood, David W Good

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Renal physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Toll-Like Receptors in Acute Kidney Injury.International journal of molecular sciences · 2021
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Bruns A WattsDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, Texas.
Esther TamayoDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, Texas.
Edward R SherwoodDepartment of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee.
David W GoodDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, Texas.
The University of Texas Medical Branch at Galveston · USVanderbilt University Medical Center · US

Funding

REGULATION OF THICK ASCENDING LIMB ACID-BASE TRANSPORTR01DK038217 · NIDDK · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI GOOD, DAVID WILLIAM · 1987 to 2019
$5.0M
NIDDK NIH HHS R01 DK038217
6 · The paper itself

Abstract

LPS inhibits

Indexed as

Adaptor Proteins, Vesicular TransportAdjuvants, ImmunologicAnimalsBicarbonatesCytoprotectionDisease Models, AnimalExtracellular Signal-Regulated MAP KinasesInterleukin-1 Receptor-Associated KinasesIntracellular Signaling Peptides and ProteinsLipid ALoop of HenleMice, Inbred C57BLMice, KnockoutMyeloid Differentiation Factor 88Phosphatidylinositol 3-KinasePhosphorylationAdaptor Proteins, Vesicular TransportAdjuvants, ImmunologicBicarbonatesExtracellular Signal-Regulated MAP KinasesInterleukin-1 Receptor-Associated KinasesIntracellular Signaling Peptides and ProteinsIrak1 protein, mouseIRAK1 protein, ratLipid Amonophosphoryl lipid AMyd88 protein, mouseMyeloid Differentiation Factor 88Phosphatidylinositol 3-KinaseTicam1 protein, mouseTlr4 protein, mouseTollip protein, mousetollip protein, ratToll-Like Receptor 4acute kidney injurymonophosphoryl lipid AsepsisToll-interacting proteinToll-like receptor signaling

Identifiers

PMID31241993
PMCPMC6766623
OpenAlexW2955216067

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.