ReviewAmerican journal of physiology. Gastrointestinal and liver physiology2019
Role of estrogen and stress on the brain-gut axis.
Review in American journal of physiology. Gastrointestinal and liver physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04716738 (Sexual Dysfunction, Quality of Life and Visceral Hyperalgesia in Women With Irritable Bowel Syndrome), which is not on this map. Cited by 44 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Sexual Dysfunction, Quality of Life and Visceral Hyperalgesia in Women With Irritable Bowel Syndrome
Who cites it
44 citing papers in PubMed, 64 citations in OpenAlex.
- Impact of D3 lymph node dissection extent on postoperative bowel function and nutritional status in right-sided colon cancer: a prospective randomized controlled trial.International journal of surgery (London, England) · 2026Trial
- Age-Related Decreases in Colonic Neurokinin A Content and Release Monitored Using Electrochemical Immunosensors.Neurogastroenterology and motility · 2026Article
- Oestrogen modulates stress-induced vagally-dependent gastric responses to oxytocin.The Journal of physiology · 2026Article
- Fructose malabsorption associated with functional abdominal bloating: Case-control study.World journal of gastrointestinal pharmacology and therapeutics · 2026Article
- Frequency and predictors of fructose malabsorption in patients with functional abdominal pain syndrome: A case-control study.World journal of gastrointestinal pathophysiology · 2026Article
- Magnetic Resonance Imaging of Gastric Motility in Conscious Rats.Neurogastroenterology and motility · 2026Article
- Acute 17β-Estradiol Administration Enhances Fear Extinction Memory and Alters Gut Microbiota in Female Rats.Biological psychiatry global open science · 2026Article
- Estrogen receptors and the NRF2 pathway: bridging hormonal regulation and stress response in the gut.Frontiers in endocrinology · 2026Review
- Painful Disorders of Gut-Brain Interaction Are More Associated With Worse Health-Related Quality of Life and Psychological Disorders Than Non-Painful Disorders in Latin American Countries.Neurogastroenterology and motility · 2025Article
- Association between the Zhejiang University index and chronic diarrhea: a cross-sectional study.European journal of medical research · 2025Article
- Association between gastrointestinal symptoms and insomnia among healthcare workers: a cross-sectional study.Scientific reports · 2025Article
- The link between gut microbiota and multiple sclerosis from the perspective of barrier function.Frontiers in immunology · 2025Review
- Lifetime estrogen exposure and domain-specific cognitive performance: results from the IGNITE study.Frontiers in aging neuroscience · 2025Article
- A study on the differences in the gut microbiota and metabolism between male and female mice in different stress periods.Experimental biology and medicine (Maywood, N.J.) · 2025Article
- Childhood obesity and central precocious puberty.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024Review
- Effect of menstrual cycle and menopause on human gastric electrophysiology.American journal of physiology. Gastrointestinal and liver physiology · 2024Article
- Gastrointestinal dysfunction in the valproic acid induced model of social deficit in rats.Autonomic neuroscience : basic & clinical · 2024Article
- Upregulation of KDM6B in the anterior cingulate cortex contributes to neonatal maternal deprivation-induced chronic visceral pain in mice.Molecular pain · 2024Article
- Article
- The relationship between gender differences in dietary habits, neuroinflammation, and Alzheimer's disease.Frontiers in aging neuroscience · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Symptoms of functional gastrointestinal disorders (FGIDs), including fullness, bloating, abdominal pain, and altered gastrointestinal (GI) motility, present a significant clinical problem, with a reported prevalence of 25%-40% within the general population. More than 60% of those affected seek and require healthcare, and affected individuals report a significantly decreased quality of life. FGIDs are highly correlated with episodes of acute and chronic stress and are increased in prevalence and reported severity in women compared with men. Although there is evidence that sex and stress interact to exacerbate FGID symptoms, the physiological mechanisms that mediate these sex-dependent disparities are incompletely understood, although hormonal-related differences in GI motility and visceral sensitivity have been purported to play a significant role in the etiology. In this mini review, we will discuss brain-gut axis control of GI motility and sensitivity, the influence of estrogen on GI motility and sensitivity, and stress modulation of the brain-gut axis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.