GuidelineNeurogastroenterology and motility2019
Guidelines on management of cyclic vomiting syndrome in adults by the American Neurogastroenterology and Motility Society and the Cyclic Vomiting Syndrome Association.
Guideline in Neurogastroenterology and motility, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Incidence and Risk Factors of Platinum-Based Chemotherapy-Induced Nausea and Vomiting: A Systematic Review and Meta-Analysis.Current oncology (Toronto, Ont.) · 2025Pooled it
- Cyclic Vomiting Syndrome in Children.Frontiers in neurology · 2020Pooled it
- Guidelines on management of cyclic vomiting syndrome in adults by the American Neurogastroenterology and Motility Society and the Cyclic Vomiting Syndrome Association.Neurogastroenterology and motility · 2019Guideline
- Malnutrition Is Common in Cyclic Vomiting Syndrome: A Prospective Study Using Validated Nutritional Assessment Tools.Digestive diseases and sciences · 2026Article
- [The cannabinoid hyperemesis syndrome-A narrative review].Der Nervenarzt · 2026Review
- Psychiatric management of pediatric cyclic vomiting syndrome using nonpharmacological interventions from a gut-brain perspective: a case report.Journal of medical case reports · 2026Article
- Rome V Pediatric Upper Gastrointestinal Disorders of Gut-Brain Interaction.Gastroenterology · 2026Review
- Avoidant-Restrictive Food Intake Disorder Is Common in Adults With Cyclic Vomiting Syndrome and Is Associated With Malnutrition.Neurogastroenterology and motility · 2026Article
- A unified framework combining linear and 3D molecular features for robust drug-protein interaction prediction.Cell reports methods · 2026Article
- Psychogastroenterology of cyclic vomiting syndrome: A crucial need to build evidence.Neurogastroenterology and motility · 2026Review
- Article
- Diagnosis and management of presumptive cyclic vomiting syndrome in a dog: first report in veterinary medicine.BMC veterinary research · 2025Article
- Sensory signals for nausea.Trends in neurosciences · 2025Review
- Prevalence and causes for chronic nausea and vomiting in adult patients-A single-centre experience.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2025Article
- Clinical Characteristics and Associated Factors in Mexican Patients With Cyclic Vomiting Syndrome and Cannabinoid Hyperemesis Syndrome.Journal of neurogastroenterology and motility · 2025Article
- Cyclic Vomiting Syndrome Versus Cannabinoid Hyperemesis Syndrome.Journal of neurogastroenterology and motility · 2025Article
- Impact of Opioid and Cannabis Use on Low-Dose Amitriptyline Efficacy in Cyclical Vomiting Syndrome: A Real-World Study in the United Kingdom.Neurogastroenterology and motility · 2025Article
- A call to action [plans] for cyclic vomiting syndrome.Neurogastroenterology and motility · 2025Review
- Cyclic vomiting syndrome: Future clinical and research priorities for: Special supplement/proceedings of 3rd international symposium.Neurogastroenterology and motility · 2025Review
- Future Applications of Central Neuromodulation and Neurophysiological Testing in Cyclic Vomiting Syndrome.Neurogastroenterology and motility · 2025Review
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
The increasing recognition of cyclic vomiting syndrome (CVS) in adults prompted the development of these evidence-based guidelines on the management of CVS in adults, which was sponsored by the American Neurogastroenterology and Motility Society (ANMS) and the Cyclic Vomiting Syndrome Association (CVSA). GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) framework was used and a professional librarian performed the literature search. The expert committee included the President of the CVSA who brought a patient perspective into the deliberations. The committee makes recommendations for the prophylaxis of CVS, treatment of acute attacks, diagnosis, and overall management of CVS. The committee strongly recommends that adults with moderate-to-severe CVS receive a tricyclic antidepressant (TCA), such as amitriptyline, as a first-line prophylactic medication and receive topiramate or aprepitant as alternate prophylactic medications. Zonisamide or levetiracetam and mitochondrial supplements (Coenzyme Q10, L-carnitine, and riboflavin) are conditionally recommended as alternate prophylactic medications, either alone or concurrently with other prophylactic medications. For acute attacks, the committee conditionally recommends using serotonin antagonists, such as ondansetron, and/or triptans, such as sumatriptan or aprepitant to abort symptoms. Emergency department treatment is best achieved with the use of an individualized treatment protocol and shared with the care team (example provided). The committee recommended screening and treatment for comorbid conditions such as anxiety, depression, migraine headache, autonomic dysfunction, sleep disorders, and substance use with referral to appropriate allied health services as indicated. Techniques like meditation, relaxation, and biofeedback may be offered as complementary therapy to improve overall well-being and patient care outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.