Evidence map›Paper›PMID 31241464›Full record

ArticleeLife2019

Imaging neuropeptide release at synapses with a genetically engineered reporter.

Keke Ding, Yifu Han, Taylor W Seid, Christopher Buser, Tomomi Karigo, Shishuo Zhang, Dion K Dickman, David J Anderson

Erratum issuedAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

  1. An opto-microperfusion neural probe for multiplexed detection of optogenetically evoked neurochemical release dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  8. Synapse-specific catecholaminergic modulation of neuronal glutamate release.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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  18. GABAeLife · 2023
    Article
  19. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Keke Ding *Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States.ORCID https://orcid.org/0000-0002-5261-4843
Yifu Han *Department of Neurobiology, University of Southern California, Los Angeles, United States.ORCID https://orcid.org/0000-0002-1201-654X
Taylor W SeidDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States.
Christopher BuserOak Crest Institute of Science, Monrovia, United States.ORCID http://orcid.org/0000-0002-4379-3878
Tomomi KarigoDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States.
Shishuo ZhangDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States.
Dion K DickmanDepartment of Neurobiology, University of Southern California, Los Angeles, United States.ORCID http://orcid.org/0000-0003-1884-284X
David J AndersonDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States.ORCID https://orcid.org/0000-0001-6175-3872

Funding

Generation of novel cell type specific mouse genetic toolsU19MH114830 · NIMH · ALLEN INSTITUTE · PI ANDERSON, DAVID J, PACHTER, LIOR S · 2017 to 2021
$64.7M
Molecular Mechanisms Governing the Homeostatic Control of Synaptic StrengthR01NS091546 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DICKMAN, DION KAI · 2015 to 2024
$4.3M
Imaging neuromodulation in the brainR37DA031389 · NIDA · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI David J Anderson · 2017 to 2026
$4.0M
Synaptic Control of Glutamate HomeostasisR01NS111414 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DICKMAN, DION KAI · 2019 to 2023
$1.8M
Imaging neuromodulation in the brainR01DA031389 · NIDA · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI ANDERSON, DAVID J · 2011 to 2015
$1.8M
Development of a scalable methodology for imaging neuropeptide release in the brainR21EY026432 · NEI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI ANDERSON, DAVID J · 2015 to 2016
$500k
NEI NIH HHS R21 EY026432NIDA NIH HHS R01 DA031389NIDA NIH HHS R37 DA031389NIH HHS NS091546NIH HHS R01DA031389NIH HHS R21EY026432NIMH NIH HHS U19 MH114830NINDS NIH HHS R01 NS091546NINDS NIH HHS R01 NS111414
6 · The paper itself

Abstract

Research on neuropeptide function has advanced rapidly, yet there is still no spatio-temporally resolved method to measure the release of neuropeptides in vivo. Here we introduce Neuropeptide Release Reporters (NPRRs): novel genetically-encoded sensors with high temporal resolution and genetic specificity. Using the

Indexed as

Genes, ReporterGenetic EngineeringMolecular ImagingAnimalsDrosophilaNeuropeptidesSynapsesNeuropeptidesdense core vesicleD. melanogasterneuropeptidesneuroscienceneurotransmission

Identifiers

PMID31241464
PMCPMC6609332

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.