Evidence map›Paper›PMID 31241251›Full record

ReviewWiley interdisciplinary reviews. Nanomedicine and nanobiotechnology2019

Use of magnetic fields and nanoparticles to trigger drug release and improve tumor targeting.

Jessica F Liu, Bian Jang, David Issadore, Andrew Tsourkas

Abstract readReview
In one paragraph

Review in Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed.

  1. Review
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  10. Spatiotemporal cancer controlNanomedicine (London, England) · 2026
    Review
  11. Review
  12. Article
  13. Advancing brain immunotherapy through functional nanomaterials.Drug delivery and translational research · 2026
    Review
  14. Magnetic nanoparticles for cancer theranostics.Biomedical physics & engineering express · 2026
    Review
  15. Review
  16. Review
  17. Article
  18. Review
  19. Innovative Nanocarriers: Magnetosomes in the Fight against Cancer.Anti-cancer agents in medicinal chemistry · 2026
    Review
  20. Review

33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jessica F LiuDepartment of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0000-0002-2663-8438
Bian JangDepartment of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania.
David IssadoreDepartment of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0000-0002-5461-8653
Andrew TsourkasDepartment of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0000-0001-7758-1753

Funding

Training Program in Neuroengineering and MedicineT32NS091006 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Brian Litt · 2015 to 2026
$4.1M
Radiation and Receptor Targeted RadioTheranostic Nanoparticles for GlioblastomaR01CA181429 · NCI · UNIVERSITY OF PENNSYLVANIA · PI DORSEY, JAY FITZGERALD · 2014 to 2018
$2.4M
A nanomagnetic platform technology to characterize traumatic brain injury using brain derived extracellular vesiclesR21MH118170 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI ISSADORE, DAVID AARON · 2018 to 2019
$414k
Spatially-targeted heating of magnetic nanoparticlesR21EB023989 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI ISSADORE, DAVID AARON · 2018 to 2019
$411k
NCI NIH HHS R01 CA181429NIBIB NIH HHS R21 EB023989NIMH NIH HHS R21 MH118170NINDS NIH HHS T32 NS091006
6 · The paper itself

Abstract

Drug delivery strategies aim to maximize a drug's therapeutic index by increasing the concentration of drug at target sites while minimizing delivery to off-target tissues. Because biological tissues are minimally responsive to magnetic fields, there has been a great deal of interest in using magnetic nanoparticles in combination with applied magnetic fields to selectively control the accumulation and release of drug in target tissues while minimizing the impact on surrounding tissue. In particular, spatially variant magnetic fields have been used to encourage accumulation of drug-loaded magnetic nanoparticles at target sites, while time-variant magnetic fields have been used to induce drug release from thermally sensitive nanocarriers. In this review, we discuss nanoparticle formulations and approaches that have been developed for magnetic targeting and/or magnetically induced drug release, as well as ongoing challenges in using magnetism for therapeutic applications. This article is categorized under: Diagnostic Tools > in vivo Nanodiagnostics and Imaging Therapeutic Approaches and Drug Discovery > Emerging Technologies Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease.

Indexed as

Drug Delivery SystemsDrug LiberationMagnetic FieldsAnimalsHumansMagnetite NanoparticlesNeoplasmsTemperatureMagnetite Nanoparticlesdrug deliverymagneticnanomaterialsnanoparticlestargeting

Identifiers

PMID31241251
PMCPMC6788948

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.