Trial reportJournal of advanced nursing2019
Impact of deep oropharyngeal suctioning on microaspiration, ventilator events, and clinical outcomes: A randomized clinical trial.
Trial report in Journal of advanced nursing, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02284178 (Oral Suction Intervention to Reduce Aspiration and Ventilator Events), which is not on this map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Oral Suction Intervention to Reduce Aspiration and Ventilator Events: NO-ASPIRATE
Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Impact of a national collaborative project to improve the care of mechanically ventilated patients.PloS one · 2023Trial
- Research on Effects of Oropharyngeal Aspiration on Incidence of Ventilator-Associated Pneumonia in Patients with Cerebral Hemorrhage in ICU.Journal of healthcare engineering · 2022Trial
- Intubation Setting, Aspiration, and Ventilator-Associated Conditions.American journal of critical care : an official publication, American Association of Critical-Care Nurses · 2020Trial
- Airway tracers and biomarkers for aspiration detection and VAP prediction in ICU patients with tracheal tubes: a systematic review and diagnostic accuracy meta-analysis.Annals of intensive care · 2026Review
- Mapping the Fine-Scale Aging Landscape of Young Chinese Women: A LOESS-Based Analysis of 45 Biophysical Skin Parameters.Clinical, cosmetic and investigational dermatology · 2026Article
- Use of Machine Learning Models to Predict Microaspiration Measured by Tracheal Pepsin A.American journal of critical care : an official publication, American Association of Critical-Care Nurses · 2025Article
- Effect of fourth hourly oropharyngeal suctioning on ventilator-associated events in patients requiring mechanical ventilation in intensive care units of a tertiary care center in South India: a randomized controlled trial.Acute and critical care · 2023Article
- Association of enteral feeding with microaspiration in critically ill adults.Applied nursing research : ANR · 2022Article
- Pepsin A in Tracheal Secretions From Patients Receiving Mechanical Ventilation.American journal of critical care : an official publication, American Association of Critical-Care Nurses · 2021Article
- Pulmonary Microbiome of Patients Receiving Mechanical Ventilation: Changes Over Time.American journal of critical care : an official publication, American Association of Critical-Care Nurses · 2021Article
- Transesophageal echocardiography-associated tracheal microaspiration and ventilator-associated pneumonia in intubated critically ill patients: a multicenter prospective observational study.Critical care (London, England) · 2020Observational
- Is α-Amylase an Important Biomarker to Detect Aspiration of Oral Secretions in Ventilated Patients?Critical care explorations · 2020Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
aimsTo evaluate a deep oropharyngeal suction intervention (NO-ASPIRATE) in intubated patients on microaspiration, ventilator-associated events and clinical outcomes.
designProspective, two-group, single-blind, randomized clinical trial.
methodsThe study was conducted between 2014 - 2017 in 513 participants enroled within 24 hr of intubation and randomized into NO-ASPIRATE or usual care groups. Standard oral care was provided to all participants every 4 hr and deep oropharyngeal suctioning was added to the NO-ASPIRATE group. Oral and tracheal specimens were obtained to quantify α-amylase as an aspiration biomarker.
resultsData were analysed for 410 study completers enrolled at least 36 hr: NO-ASPIRATE (N = 206) and usual care (N = 204). Percent of tracheal specimens positive for α-amylase, mean tracheal α-amylase levels over time and ventilator-associated events were not different between groups. The NO-ASPIRATE group had a shorter hospital length of stay and a subgroup with moderate aspiration at baseline had significantly lower α-amylase levels across time.
conclusionHospital length of stay was shorter in the NO-ASPIRATE group and a subgroup of intervention participants had lower α-amylase across time. Delivery of standardized oral care to all participants may have been an intervention itself and possibly associated with the lack of significant findings for most outcomes. IMPACT: This trial compared usual care to oral care with a deep suctioning intervention on microaspiration and ventilator-associated events, as this has not been systematically studied. Further research on the usefulness of α-amylase as an aspiration biomarker and the role of oral suctioning, especially for certain populations, is indicated. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov: NCT02284178.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.