ArticleProceedings of the National Academy of Sciences of the United States of America1988
Induction of fibronectin gene transcription and mRNA is a primary response to growth-factor stimulation of AKR-2B cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 193 citations in OpenAlex.
- Tissue repair processes in healing chronic pressure ulcers treated with recombinant platelet-derived growth factor BB.The American journal of pathology · 1994Trial
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- "Advancing cardiac patch viability and functionality: innovations in scaffold design and cellular optimization".Journal of materials science. Materials in medicine · 2025Review
- The Effects of Combined Exposure to Simulated Microgravity, Ionizing Radiation, and Cortisol on theCells · 2023Article
- Efficient transdermal delivery of functional protein cargoes by a hydrophobic peptide MTD 1067.Scientific reports · 2022Article
- Impact of human adipose tissue-derived stem cells on dermatofibrosarcoma protuberans cells in an indirect co-culture: an in vitro study.Stem cell research & therapy · 2021Article
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- Fibronectin expression is upregulated by PI-3K/Akt activation in tamoxifen-resistant breast cancer cells.BMB reports · 2017Article
- A Novel Technique for Conjunctivoplasty in a Rabbit Model: Platelet-Rich Fibrin Membrane Grafting.Journal of ophthalmology · 2016Article
- Integrins are the necessary links to hypertrophic growth in cardiomyocytes.Journal of signal transduction · 2011Article
- Mislocalized scaffolding by the Na-H exchanger NHE1 dominantly inhibits fibronectin production and TGF-beta activation.Molecular biology of the cell · 2009Article
- The role of PDGF in radiation oncology.Radiation oncology (London, England) · 2007Review
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- Mechanism of human dermal fibroblast migration driven by type I collagen and platelet-derived growth factor-BB.Molecular biology of the cell · 2004Article
- Platelet-derived growth factor gene delivery stimulates ex vivo gingival repair.Tissue engineering · 2003Article
- Article
- Epidermal growth factor increases the level of the cyclin-dependent kinase (CDK) inhibitor p21/CIP1 (CDK-interacting protein 1) in A431 cells by increasing the half-lives of the p21/CIP1 transcript and the p21/CIP1 protein.The Biochemical journal · 1999Article
- The effects of ageing on wound healing: immunolocalisation of growth factors and their receptors in a murine incisional model.Journal of anatomy · 1997Article
- Characterization of mouse fibronectin alternative mRNAs reveals an unusual isoform present transiently during liver development.Gene expression · 1996Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
A cDNA library, prepared from poly(A)+ RNA isolated from quiescent AKR-2B cells 4 hr after stimulation with epidermal growth factor in the presence of cycloheximide, was screened to identify RNA transcripts whose abundance is specifically increased as a primary response to growth stimulation. Approximately 40% of the inducible clones detected by this procedure corresponded to either cytoskeletal beta- or gamma-actin genes. One nonactin clone, designated c99, was found to be derived from an 8.5-kilobase RNA whose abundance began to increase as early as 30 min after stimulation. DNA sequencing established the identity of this RNA as fibronectin. Several additional mitogens were then tested and found to efficiently induce fibronectin mRNA. These included fetal calf serum, platelet-derived growth factor, and transforming growth factor type beta. For at least one inducer, fetal calf serum, the increase in mRNA was preceded by an increase in fibronectin gene transcription. This increase was rapid, reaching maximal levels within 10 min, and was accompanied by near-coordinate increases in both c-fos and beta-actin transcription. These results indicate that fibronectin is a member of a class of "early-response" genes, typified by c-fos and including beta-actin, whose rapid expression may be important in mediating cellular responses to peptide growth factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.