ArticleProceedings of the National Academy of Sciences of the United States of America1988
Dynamic membrane-cytoskeletal interactions: specific association of integrin and talin arises in vivo after phorbol ester treatment of peripheral blood lymphocytes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
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Who cites it
59 citing papers in PubMed, 227 citations in OpenAlex.
- Leflunomide, a novel immunomodulating drug, inhibits homotypic adhesion of peripheral blood and synovial fluid mononuclear cells in rheumatoid arthritis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 1996Trial
- Article
- Regulation of thymocyte trafficking by Tagap, a GAP domain protein linked to human autoimmunity.Science signaling · 2018Article
- TAGLN2 regulates T cell activation by stabilizing the actin cytoskeleton at the immunological synapse.The Journal of cell biology · 2015Article
- The role of phosphoinositide-regulated actin reorganization in chemotaxis and cell migration.British journal of pharmacology · 2014Review
- Mechanisms of talin-dependent integrin signaling and crosstalk.Biochimica et biophysica acta · 2014Review
- Article
- Normal and abnormal secretion by haemopoietic cells.Immunology · 2001Review
- Dynamic interactions of macrophages with T cells during antigen presentation.The Journal of experimental medicine · 1999Article
- Cell-matrix adhesions differentially regulate fascin phosphorylation.Molecular biology of the cell · 1999Article
- Layilin, a novel talin-binding transmembrane protein homologous with C-type lectins, is localized in membrane ruffles.The Journal of cell biology · 1998Article
- Induction of Sp1 in differentiating human embryonal carcinoma cells triggers transcription of the fibronectin gene.Molecular and cellular biology · 1998Article
- LFA-1-mediated adhesion is regulated by cytoskeletal restraint and by a Ca2+-dependent protease, calpain.The Journal of cell biology · 1998Article
- Opening-up of liposomal membranes by talin.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Cytoplasmic tails of beta 1, beta 2, and beta 7 integrins differentially regulate LFA-1 function in K562 cells.Molecular biology of the cell · 1997Article
- Dual role of the actin cytoskeleton in regulating cell adhesion mediated by the integrin lymphocyte function-associated molecule-1.Molecular biology of the cell · 1997Article
- The effect of overexpression of the protein tyrosine phosphatase PTPMEG on cell growth and on colony formation in soft agar in COS-7 cells.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Talin requires beta-integrin, but not vinculin, for its assembly into focal adhesion-like structures in the nematode Caenorhabditis elegans.Molecular biology of the cell · 1996Article
- G10BP, an E1A-inducible negative regulator of Sp1, represses transcription of the rat fibronectin gene.Molecular and cellular biology · 1995Article
- Mapping in vivo associations of cytoplasmic proteins with integrin beta 1 cytoplasmic domain mutants.Molecular biology of the cell · 1995Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Members of the family of transmembrane integral membrane proteins called integrins have been implicated in forming attachments to actin microfilaments of the cytoskeleton. These attachments are thought to involve one or more intervening peripheral membrane proteins linked to integrin. To detect such possible linkages in vivo, the integrin molecules on the surfaces of intact chicken peripheral blood lymphocytes were collected into caps by cross-linking with specific antibodies, and the capped cells were examined by double immunofluorescence to determine whether particular cytoskeletal proteins were co-collected with the integrin. With resting lymphocytes, the capping of integrin did not result in any detectable redistribution of either talin, vinculin, or alpha-actinin inside the cells. However, if the capping was carried out upon the addition of phorbol 12-myristate 13-acetate (PMA) to the cells, then talin, but not vinculin or alpha-actinin, was found associated with the integrin caps. PMA is known to activate protein kinase C. These results suggest that after, but not before, PMA stimulation of intact cells, talin becomes linked either directly or indirectly with integrin, reflecting the formation of a membrane-cytoskeletal association that is metabolically regulated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.