Evidence map›Paper›PMID 31241019›Full record

ArticleAnti-inflammatory & anti-allergy agents in medicinal chemistry2020

Comparative Evaluation of Colon Cancer Specific Antigen-2 Test and Chromocolonoscopy for Early Detection of Egyptian Patients with Colorectal Cancer.

Marwa Elhossary, Nehah Hawash, Rehab Badawi, Mohamed Yousef, Sherief Abd-Elsalam, Mohammed Elhendawy, Rania Wasfy, Sabry Abou-Saif, Amal ElBendary, Saber Ismail

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Anti-inflammatory & anti-allergy agents in medicinal chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Marwa ElhossaryTropical Medicine Department, Tanta University, Tanta, Egypt.
Nehah HawashTropical Medicine Department, Tanta University, Tanta, Egypt.
Rehab BadawiTropical Medicine Department, Tanta University, Tanta, Egypt.
Mohamed YousefTropical Medicine Department, Tanta University, Tanta, Egypt.
Sherief Abd-ElsalamTropical Medicine Department, Tanta University, Tanta, Egypt.
Mohammed ElhendawyTropical Medicine Department, Tanta University, Tanta, Egypt.
Rania WasfyPathology Department, Tanta University, Tanta, Egypt.
Sabry Abou-SaifTropical Medicine Department, Tanta University, Tanta, Egypt.
Amal ElBendaryClinical Pathology Department, Tanta University, Tanta, Egypt.
Saber IsmailTropical Medicine Department, Tanta University, Tanta, Egypt.
Tanta University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEffective screening of colorectal cancer (CRC) in early stage could reduce the advancement of CRC and therefore mortality. Effective screening is based on either stool dependent tests or colon dependent examination.

aimsThe aim of the study was a comparative evaluation of chromocolonoscopy and Colon Cancer-Specific Antigen-2 test for early detection of colorectal cancer in Egyptian patients.

methodsThis case control study was carried out on 55 patients classified into 3 groups: Group I consisted of twenty patients with precancerous lesions detected by colonoscopy, Group II consisted of twenty patients diagnosed with colorectal cancer and Group III consisted of fifteen individuals (who underwent colonoscopy for other indications) as a control group. All the subjects were subjected to measure occult blood in the stool, measurement of Colon Cancer-Specific Antigen-2 level in serum and tissue and chromo colonoscopy using Indigo Carmine stain.

resultsIn group II, there was a statistically significant increase in CCSA2 in serum as compared to the other 2 groups. Cutoff >11.3 CCSA2 in serum showed 65% sensitivity, 85% specificity, 81.2% PPV, 70.8% NPV and 70.3% accuracy in the differentiation of group II with cancer colon from group I with premalignant colonic lesions. A cutoff > 9.1 CCSA2 in serum showed 95% sensitivity, 46.67% specificity, 70.4% PPV, 87.5% NPV and 73.5% accuracy in differentiating group II with cancer colon from normal controls (group III).

conclusionCCSA-2 level in serum was significantly higher in cancer colon. Chromoendoscopy has a role in the detection of polyps, both neoplastic and non-neoplastic.

Indexed as

Colorectal NeoplasmsAntigens, NeoplasmBiomarkers, TumorCase-Control StudiesColonic PolypsColonoscopyEarly Detection of CancerEgyptFemaleHumansMaleMiddle AgedNuclear ProteinsPrecancerous ConditionsPredictive Value of TestsAntigens, NeoplasmBiomarkers, Tumorcolon cancer-specific antigen 2, humanNuclear Proteinschromocolonoscopy.Colorectal cancerdysplasiapolypsscreeningsurveillance

Identifiers

PMID31241019
PMCPMC7499350
OpenAlexW2954272865

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.