ArticleJournal of biomedical optics2019
Revealing brain pathologies with multimodal visible light optical coherence microscopy and fluorescence imaging.
Article in Journal of biomedical optics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Visible Light Optical Coherence Tomography: Technology and Biomedical Applications.Bioengineering (Basel, Switzerland) · 2025Review
- Visible-light optical coherence tomography and its applications.Neurophotonics · 2025Review
- Computational 3D resolution enhancement for optical coherence tomography with a narrowband visible light source.Biomedical optics express · 2023Article
- MRI/fluorescence dual-mode probe: its simple preparation method and imaging application in vitro.Biomedical optics express · 2022Article
- Non-destructive characterization of adult zebrafish models using Jones matrix optical coherence tomography.Biomedical optics express · 2022Article
- Multi-Modal Optical Imaging and Combined Phototherapy of Nasopharyngeal Carcinoma Based on a Nanoplatform.International journal of nanomedicine · 2022Review
- Medical Image Segmentation Algorithm for Three-Dimensional Multimodal Using Deep Reinforcement Learning and Big Data Analytics.Frontiers in public health · 2022Article
- Reconstruction of visible light optical coherence tomography images retrieved from discontinuous spectral data using a conditional generative adversarial network.Biomedical optics express · 2021Article
- Capability of physically reasonable OCT-based differentiation between intact brain tissues, human brain gliomas of different WHO grades, and glioma model 101.8 from rats.Biomedical optics express · 2020Article
- Improved Diagnostic Imaging of Brain Tumors by Multimodal Microscopy and Deep Learning.Cancers · 2020Article
- Gabor domain optical coherence microscopy combined with laser scanning confocal fluorescence microscopy.Biomedical optics express · 2019Article
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Authors and funding
13 authors.
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Abstract
We present a multimodal visible light optical coherence microscopy (OCM) and fluorescence imaging (FI) setup. Specification and phantom measurements were performed to characterize the system. Two applications in neuroimaging were investigated. First, curcumin-stained brain slices of a mouse model of Alzheimer's disease were examined. Amyloid-beta plaques were identified based on the fluorescence of curcumin, and coregistered morphological images of the brain tissue were provided by the OCM channel. Second, human brain tumor biopsies retrieved intraoperatively were imaged prior to conventional neuropathologic work-up. OCM revealed the three-dimensional structure of the brain parenchyma, and FI added the tumor tissue-specific contrast. Attenuation coefficients computed from the OCM data and the florescence intensity values were analyzed and showed a statistically significant difference for 5-aminolevulinic acid (5-ALA)-positive and -negative brain tissues. OCM findings correlated well with malignant hot spots within brain tumor biopsies upon histopathology. The combination of OCM and FI seems to be a promising optical imaging modality providing complementary contrast for applications in the field of neuroimaging.
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