ArticleAnnals of laboratory medicine2019
Application of the Whole Genome-Based Bacterial Identification System, TrueBac ID, Using Clinical Isolates That Were Not Identified With Three Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) Systems.
Article in Annals of laboratory medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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71 citing papers in PubMed.
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- Complete genome sequence of a carbon tetrachloride-degrading bacterium,Microbiology resource announcements · 2025Article
- Genomic and taxonomic characterization of the Comamonas sp. nov., a bacterium isolated from Brazilian Cerrado soil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
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- Community-acquired pneumonia caused by Micrococcus antarcticus: a rare case report.BMC infectious diseases · 2024Article
- Genotypic and Phenotypic Characterization ofMicroorganisms · 2024Article
- Rapid Classification and Differentiation of Sepsis-Related Pathogens Using FT-IR Spectroscopy.Microorganisms · 2024Article
- Delay in the diagnosis of Brucella abortus bacteremia in a nonendemic country: a case report.BMC infectious diseases · 2024Article
- Terrihabitans rhizophilus sp. nov., isolated from the rhizosphere soil of plant in temperate semi-arid steppe.Antonie van Leeuwenhoek · 2024Article
- Novel Organism Verification and Analysis (NOVA) study: identification of 35 clinical isolates representing potentially novel bacterial taxa using a pipeline based on whole genome sequencing.BMC microbiology · 2024Article
- Comparative genomic characterization ofFrontiers in microbiology · 2024Article
11 more citing papers are in PubMed but not listed here.
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Abstract
backgroundNext-generation sequencing is increasingly used for taxonomic identification of pathogenic bacterial isolates. We evaluated the performance of a newly introduced whole genome-based bacterial identification system, TrueBac ID (ChunLab Inc., Seoul, Korea), using clinical isolates that were not identified by three matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) systems and 16S rRNA gene sequencing.
methodsThirty-six bacterial isolates were selected from a university-affiliated hospital and a commercial clinical laboratory. Species was identified by three MALDI-TOF MS systems: Bruker Biotyper MS (Bruker Daltonics, Billerica, MA, USA), VITEK MS (bioMérieux, Marcy l'Étoile, France), and ASTA MicroIDSys (ASTA Inc., Suwon, Korea). Whole genome sequencing was conducted using the Illumina MiSeq system (Illumina, San Diego, CA, USA), and genome-based identification was performed using the TrueBac ID cloud system (www.truebacid.com).
resultsTrueBac ID assigned 94% (34/36) of the isolates to known (N=25) or novel (N=4) species, genomospecies (N=3), or species group (N=2). The remaining two were identified at the genus level.
conclusionsTrueBac ID successfully identified the majority of isolates that MALDI-TOF MS failed to identify. Genome-based identification can be a useful tool in clinical laboratories, with its superior accuracy and database-driven operations.
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