ReviewObesity reviews : an official journal of the International Association for the Study of Obesity2019
Lipotoxicity plays a key role in the development of both insulin resistance and muscle atrophy in patients with type 2 diabetes.
Review in Obesity reviews : an official journal of the International Association for the Study of Obesity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers, 5 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
124 citing papers in PubMed, 5 syntheses or guidelines pooled it, 207 citations in OpenAlex.
- Correlation between low handgrip strength and metabolic syndrome in older adults: a systematic review.Archives of endocrinology and metabolism · 2024Pooled it
- Pooled it
- Effects of vegan diets on cardiometabolic health: A systematic review and meta-analysis of randomized controlled trials.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022Pooled it
- Antioxidant and Anti-Inflammatory Properties of Hydroxyl Safflower Yellow a in Diabetic Nephropathy: A Meta-Analysis of Randomized Controlled Trials.Frontiers in pharmacology · 2022Pooled it
- The Impact of Vegan Diet in the Prevention and Treatment of Type 2 Diabetes: A Systematic Review.Nutrients · 2021Pooled it
- Trial
- Beyond energy balance: 2-arachidonoylglycerol at the crossroads of obesity, inflammation, and metabolic dysfunction.Molecular biology reports · 2026Review
- Endocannabinoid system and skeletal muscle health: Insights from cannabidiol.Molecular metabolism · 2026Review
- Revisiting cannabinoid receptor-2: a key regulator of hepatic steatosis, inflammatory cascades, and fibrotic progression.Archives of toxicology · 2026Review
- Increased epicardial adipose tissue area and radiodensity in sarcopenic obesity.Cardiovascular diabetology · 2026Article
- Interplay between sarcopenia and type 2 diabetes: mechanisms, implications, and therapeutic prospects.Nutrition & diabetes · 2026Review
- Muscle Ultrasound Echo Intensity Detects Insulin Resistance Before Changes in HbAJournal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2026Article
- Prevalence and risk factors for metabolic dysfunction-associated steatotic liver disease in Sweden: Insights from the SCAPIS cohort.Journal of internal medicine · 2026Article
- Nanozymes for Liver Disease Therapy: Advances in Catalytic Activity, Targeting Strategies, and Clinical Translation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Type 2 Diabetes Mellitus as a Multisystem Disease: From Insulin Resistance to Organ Crosstalk-A Narrative Review.Biomedicines · 2026Review
- Identification and verification of the key genes, CCR1 and EGR2, in diabetes-associated lipophagy.Scientific reports · 2026Article
- Epigenetic regulation by DNA methylation in PCOS and POI: mechanisms of ovarian dysfunction and implications for clinical research.Journal of ovarian research · 2026Review
- Association between diabetes and sarcopenia in US adults and the role of adiposity: a survey-weighted analysis of NHANES 2011-2018.BMC public health · 2026Article
- Associations Between Triglycerides and Walking Capacity in Community-Dwelling Older Adults with Metabolic Syndrome.Diseases (Basel, Switzerland) · 2026Article
- Passiflora edulis f. flavicarpa Extract Prevents Muscle Atrophy and Insulin Resistance in High-Fat Diet-Induced Obese Rats via Regulating the Nrf2, NF-κB, and IRS-1/PI3K/AKT Signaling Pathways.Oxidative medicine and cellular longevity · 2026Article
64 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insulin resistance and muscle mass loss often coincide in individuals with type 2 diabetes. Most patients with type 2 diabetes are overweight, and it is well established that obesity and derangements in lipid metabolism play an important role in the development of insulin resistance in these individuals. Specifically, increased adipose tissue mass and dysfunctional adipose tissue lead to systemic lipid overflow and to low-grade inflammation via altered secretion of adipokines and cytokines. Furthermore, an increased flux of fatty acids from the adipose tissue may contribute to increased fat storage in the liver and in skeletal muscle, resulting in an altered secretion of hepatokines, mitochondrial dysfunction, and impaired insulin signalling in skeletal muscle. Recent studies suggest that obesity and lipid derangements in adipose tissue can also lead to the development of muscle atrophy, which would make insulin resistance and muscle atrophy two sides of the same coin. Unfortunately, the exact relationship between lipid accumulation, type 2 diabetes, and muscle atrophy remains largely unexplored. The aim of this review is to discuss the relationship between type 2 diabetes and muscle loss and to discuss some of the joint pathways through which lipid accumulation in organs may affect peripheral insulin sensitivity and muscle mass.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.