ArticleAddiction (Abingdon, England)2019
Polygenic risk for alcohol misuse is moderated by romantic partnerships.
Article in Addiction (Abingdon, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of gene-by-intervention studies of alcohol and other substance use.Development and psychopathology · 2021Pooled it
- Associations of Romantic Partners' Characteristics with Alcohol Consumption and Binge Drinking: Examining Evidence for Gene-Environment Interaction.Clinical psychological science : a journal of the Association for Psychological Science · 2025Article
- Genetic risk for trait aggression and alcohol use predict unique facets of alcohol-related aggression.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2025Article
- Marital status and genetic liability independently predict coronary heart disease incidence.Scandinavian journal of public health · 2024Article
- The Collaborative Study on the Genetics of Alcoholism: Overview.Genes, brain, and behavior · 2023Review
- Examining interactions between polygenic scores and interpersonal trauma exposure on alcohol consumption and use disorder in an ancestrally diverse college cohort.Frontiers in genetics · 2023Article
- Racial Discrimination and Alcohol Problems: Examining Interactions with Genetic Risk and Impulsivity among African American Young Adults.Journal of youth and adolescence · 2022Article
- Changing associations of coronary heart disease incidence with current partnership status and marital history over three decades.SSM - population health · 2022Article
- Marital Satisfaction as a Moderator of Molecular Genetic Influences on Mental Health.Clinical psychological science : a journal of the Association for Psychological Science · 2021Article
- Gene-environment dependencies lead to collider bias in models with polygenic scores.Scientific reports · 2021Article
- Characterization of alcohol polygenic risk scores in the context of mental health outcomes: Within-individual and intergenerational analyses in the Avon Longitudinal Study of Parents and Children.Drug and alcohol dependence · 2021Article
- Multivariable G-E interplay in the prediction of educational achievement.PLoS genetics · 2020Observational
- Sex differences in the relative influence of marital status and parenthood on alcohol use disorder symptoms: A multilevel discordant twin design.Journal of abnormal psychology · 2020Article
- Using polygenic scores for identifying individuals at increased risk of substance use disorders in clinical and population samples.Translational psychiatry · 2020Article
- FinnTwin12 Cohort: An Updated Review.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2019Review
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9 authors.
Funding
Abstract
BACKGROUND AND
aimsPrevious twin research suggests relationship status can moderate underlying genetic liability towards alcohol misuse. This paper examined: (1) whether genome-wide polygenic scores (GPS) for alcohol consumption are associated with alcohol misuse; (2) whether these GPS are moderated by romantic relationships (gene-environment interaction; G × E) and (3) whether G × E results are consistent across sex.
designLinear mixed-effects models were used to test associations between genome-wide polygenic scores, relationship status and alcohol use/misuse.
settingFinnish twins born between 1983 and 1987 identified through Finland's central population registry.
participantsAn intensively studied subset of Finnish Twin Study (FinnTwin12) during the young adult phase (aged 20-26 years). The analytical sample includes those with complete interview and genetic data (n = 1201). MEASUREMENTS: Key measurements included involvement in a romantic partnership, drinking frequency, intoxication frequency and DSM-IV alcohol dependence (AD) symptoms. Genome-wide polygenic scores (GPS) were created from available summary statistics from a large genome-wide association study (GWAS) of drinks per week.
resultsGPS predicted drinking frequency [b = 0.109; 95% confidence interval (CI) = 0.050, 0.168], intoxication frequency (b = 0.111; 95% CI = 0.054, 0.168) and AD symptoms (b = 0.123; 95% CI = 0.064, 0.182). Having a romantic relationship negatively influenced the association between GPS and drinking frequency (b = -0.105; 95% CI = -0.211, -0.001), intoxication frequency (b = -0.118; 95% CI = -0.220, -0.016) and AD symptoms (b = -0.119; 95% CI = -0.229, -0.009). There was a three-way interaction between sex, relationship status and GPS for intoxication frequency (b = 0.223; 95% CI = 0.013, 0.433), such that the reduced association between GPS and intoxication frequency for those in a relationship was only apparent in males. We found no evidence of three-way interactions for drinking frequency or AD symptoms.
conclusionsBeing in a romantic relationship reduced the association between genetic predisposition and drinking, high-risk drinking and alcohol problems. However, for high-risk drinking the protective effect was limited to males, mapping onto earlier findings suggesting that males benefit more from romantic partnerships.
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