Evidence map›Paper›PMID 31240519›Full record

ArticleMolecular diversity2020

Differential modulation of SIRT6 deacetylase and deacylase activities by lysine-based small molecules.

Giovanna Sociali, Nara Liessi, Alessia Grozio, Irene Caffa, Marco Daniele Parenti, Silvia Ravera, Bruno Tasso, Andrea Benzi, Alessio Nencioni, Alberto Del Rio and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular diversity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Emerging Therapeutic Potential of SIRT6 Modulators.Journal of medicinal chemistry · 2021
    Review
  5. Review
  6. Review
  7. Article
  8. Sirtuins and SIRT6 in Carcinogenesis and in Diet.International journal of molecular sciences · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Giovanna SocialiDepartment of Experimental Medicine, Section of Biochemistry, and CEBR, University of Genoa, V.le Benedetto XV 1, 16132, Genoa, Italy.
Nara LiessiDepartment of Experimental Medicine, Section of Biochemistry, and CEBR, University of Genoa, V.le Benedetto XV 1, 16132, Genoa, Italy.
Alessia GrozioDepartment of Experimental Medicine, Section of Biochemistry, and CEBR, University of Genoa, V.le Benedetto XV 1, 16132, Genoa, Italy.
Irene CaffaDepartment of Internal Medicine, University of Genoa, V.le Benedetto XV 6, 16132, Genoa, Italy.
Marco Daniele ParentiInstitute of Organic Synthesis and Photoreactivity (ISOF), National Research Council (CNR), Via P. Gobetti 101, 40129, Bologna, Italy.
Silvia RaveraDepartment of Experimental Medicine, Section of Anatomy, University of Genova, Via Leon Battista Alberti 2, 16132, Genoa, Italy.
Bruno TassoDepartment of Pharmacy, Section of Medicinal Chemistry, School of Medical and Pharmaceutical Sciences, University of Genoa, Viale Benedetto XV, 3, 16132, Genoa, Italy.
Andrea BenziDepartment of Experimental Medicine, Section of Biochemistry, and CEBR, University of Genoa, V.le Benedetto XV 1, 16132, Genoa, Italy.
Alessio NencioniDepartment of Internal Medicine, University of Genoa, V.le Benedetto XV 6, 16132, Genoa, Italy.
Alberto Del RioInstitute of Organic Synthesis and Photoreactivity (ISOF), National Research Council (CNR), Via P. Gobetti 101, 40129, Bologna, Italy.
Inmaculada RobinaDepartment of Organic Chemistry, Faculty of Chemistry, University of Seville, C/Prof. García González, 1, 41012, Seville, Spain.
Enrico MilloDepartment of Experimental Medicine, Section of Biochemistry, and CEBR, University of Genoa, V.le Benedetto XV 1, 16132, Genoa, Italy. enrico.millo@unige.it.
Santina BruzzoneDepartment of Experimental Medicine, Section of Biochemistry, and CEBR, University of Genoa, V.le Benedetto XV 1, 16132, Genoa, Italy. santina.bruzzone@unige.it.ORCID http://orcid.org/0000-0003-2034-3716
University of Genoa · ITInstitute of Organic Synthesis and Photoreactivity · ITOspedale Policlinico San Martino · ITUniversidad de Sevilla · ESWashington University in St. Louis · US

Funding

Administration for Community Living (US) BC161452P1Associazione Italiana per la Ricerca sul Cancro #22098Associazione Italiana per la Ricerca sul Cancro IG #17736Associazione Italiana per la Ricerca sul Cancro IG #19172Associazione Italiana per la Ricerca sul Cancro start-up #6266Collegio Ghislieri di Pavia fellowshipFondazione Italiana Sclerosi Multipla 2017/R/6FP7 GA #256986Ministerio de Economía y Competitividad CTQ2016-77270-RMinistero della Salute GR-2011-02347192
6 · The paper itself

Abstract

Sirtuin 6 (SIRT6) is an NAD

Indexed as

Drug DesignEnzyme InhibitorsLysineSirtuinsSmall Molecule LibrariesTumor Necrosis Factor-alphaEnzyme InhibitorsLysineSirtuinsSmall Molecule LibrariesTumor Necrosis Factor-alphaMolecular designSirtuinsSmall molecule SIRT6 modulators

Identifiers

PMID31240519
OpenAlexW2954209632

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.