ArticleCerebral cortex (New York, N.Y. : 1991)2020
Corticosteroids and Regional Variations in Thickness of the Human Cerebral Cortex across the Lifespan.
Article in Cerebral cortex (New York, N.Y. : 1991), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Human-specific features of the cerebellum and ZP2-regulated synapse development.bioRxiv : the preprint server for biology · 2025Article
- General and specific patterns of cortical gene expression as spatial correlates of complex cognitive functioning.Human brain mapping · 2024Article
- General and specific patterns of cortical gene expression as spatial correlates of complex cognitive functioning.bioRxiv : the preprint server for biology · 2023Article
- Overlapping brain correlates of superior cognition among children at genetic risk for Alzheimer's disease and/or major depressive disorder.Scientific reports · 2023Article
- Early-life stress exposure and large-scale covariance brain networks in extremely preterm-born infants.Translational psychiatry · 2022Article
- The effect of perceived stress on cognition is mediated by personality and the underlying neural mechanism.Translational psychiatry · 2022Article
- The role of glucocorticoid receptor gene in the association between attention deficit-hyperactivity disorder and smaller brain structures.Journal of neural transmission (Vienna, Austria : 1996) · 2021Article
- A variant near DHCR24 associates with microstructural properties of white matter and peripheral lipid metabolism in adolescents.Molecular psychiatry · 2021Article
- Mineralocorticoid Receptor Antagonists in Diabetic Kidney Disease.Frontiers in pharmacology · 2021Review
- Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders.JAMA psychiatry · 2021Article
- Assessment of Neurobiological Mechanisms of Cortical Thinning During Childhood and Adolescence and Their Implications for Psychiatric Disorders.JAMA psychiatry · 2020Article
Corrections and comments
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Authors and funding
32 authors at 19 institutions in 10 countries.
Funding
Abstract
Exposures to life stressors accumulate across the lifespan, with possible impact on brain health. Little is known, however, about the mechanisms mediating age-related changes in brain structure. We use a lifespan sample of participants (n = 21 251; 4-97 years) to investigate the relationship between the thickness of cerebral cortex and the expression of the glucocorticoid- and the mineralocorticoid-receptor genes (NR3C1 and NR3C2, respectively), obtained from the Allen Human Brain Atlas. In all participants, cortical thickness correlated negatively with the expression of both NR3C1 and NR3C2 across 34 cortical regions. The magnitude of this correlation varied across the lifespan. From childhood through early adulthood, the profile similarity (between NR3C1/NR3C2 expression and thickness) increased with age. Conversely, both profile similarities decreased with age in late life. These variations do not reflect age-related changes in NR3C1 and NR3C2 expression, as observed in 5 databases of gene expression in the human cerebral cortex (502 donors). Based on the co-expression of NR3C1 (and NR3C2) with genes specific to neural cell types, we determine the potential involvement of microglia, astrocytes, and CA1 pyramidal cells in mediating the relationship between corticosteroid exposure and cortical thickness. Therefore, corticosteroids may influence brain structure to a variable degree throughout life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.