ArticleCommunications biology2019
Paternal exposure to benzo(a)pyrene induces genome-wide mutations in mouse offspring.
Article in Communications biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- Dissecting Oxidative Stress and Organismic Response to a Temperature Gradient in the MidgeEcology and evolution · 2025Article
- Duplex sequencing identifies unique characteristics of ENU-induced mutations in male mouse germ cells†.Biology of reproduction · 2025Article
- Germline mosaicism in TCF20-associated neurodevelopmental disorders: a case study and literature review.Journal of human genetics · 2025Review
- Carcinogen exposure enhances cancer immunogenicity by blocking the development of an immunosuppressive tumor microenvironment.The Journal of clinical investigation · 2023Article
- Effects of Benzo[a]pyrene on Human Sperm Functions: An In Vitro Study.International journal of molecular sciences · 2023Article
- Beyond Genes: Germline Disruption in the Etiology of Autism Spectrum Disorders.Journal of autism and developmental disorders · 2022Article
- Heritable consequences of paternal nicotine exposure: from phenomena to mechanisms†.Biology of reproduction · 2021Review
- Differences in the number of de novo mutations between individuals are due to small family-specific effects and stochasticity.Genome research · 2021Article
- Benzo[International journal of molecular sciences · 2021Article
- Heritable hazards of smoking: Applying the "clean sheet" framework to further science and policy.Environmental and molecular mutagenesis · 2020Article
- Inferring evolutionary dynamics of mutation rates through the lens of mutation spectrum variation.Current opinion in genetics & development · 2020Review
- In utero Exposure to Genotoxicants Leading to Genetic Mosaicism: An Overlooked Window of Susceptibility in Genetic Toxicology Testing?Environmental and molecular mutagenesis · 2020Article
- Mutation Induction in Humans and Mice: Where Are We Now?Cancers · 2019Review
- DNA Copy Number Variations as Markers of Mutagenic Impact.International journal of molecular sciences · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding the effects of environmental exposures on germline mutation rates has been a decades-long pursuit in genetics. We used next-generation sequencing and comparative genomic hybridization arrays to investigate genome-wide mutations in the offspring of male mice exposed to benzo(a)pyrene (BaP), a common environmental pollutant. We demonstrate that offspring developing from sperm exposed during the mitotic or post-mitotic phases of spermatogenesis have significantly more de novo single nucleotide variants (1.8-fold;
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.