Evidence map›Paper›PMID 31240265›Full record

ArticleCommunications biology2019

MCRIP1 promotes the expression of lung-surfactant proteins in mice by disrupting CtBP-mediated epigenetic gene silencing.

Jane S Weng, Takanori Nakamura, Hisashi Moriizumi, Hiroshi Takano, Ryoji Yao, Mutsuhiro Takekawa

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jane S Weng1Division of Cell Signaling and Molecular Medicine, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639 Japan.
Takanori Nakamura1Division of Cell Signaling and Molecular Medicine, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639 Japan.
Hisashi Moriizumi1Division of Cell Signaling and Molecular Medicine, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639 Japan.
Hiroshi Takano3Division of Cell Biology, Cancer Institute, Japanese Foundation for Cancer Research, Koto-ku, Tokyo 135-8550 Japan.
Ryoji Yao3Division of Cell Biology, Cancer Institute, Japanese Foundation for Cancer Research, Koto-ku, Tokyo 135-8550 Japan.
Mutsuhiro Takekawa1Division of Cell Signaling and Molecular Medicine, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639 Japan.ORCID 0000-0002-8027-3847
The University of Tokyo · JPJapanese Foundation For Cancer Research · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Proper regulation of epigenetic states of chromatin is crucial to achieve tissue-specific gene expression during embryogenesis. The lung-specific gene products, surfactant proteins B (SP-B) and C (SP-C), are synthesized in alveolar epithelial cells and prevent alveolar collapse. Epigenetic regulation of these surfactant proteins, however, remains unknown. Here we report that MCRIP1, a regulator of the CtBP transcriptional co-repressor, promotes the expression of SP-B and SP-C by preventing CtBP-mediated epigenetic gene silencing. Homozygous deficiency of

Indexed as

Alcohol OxidoreductasesAnimalsCell Line, TumorCo-Repressor ProteinsDNA-Binding ProteinsEpitheliumForkhead Transcription FactorsGene ExpressionGene SilencingHumansIntracellular Signaling Peptides and ProteinsLungMice, Inbred C57BLMice, KnockoutPulmonary Surfactant-Associated Protein BPulmonary Surfactant-Associated Protein CAlcohol OxidoreductasesCo-Repressor ProteinsCtbp2 protein, mouseC-terminal binding proteinDNA-Binding ProteinsForkhead Transcription FactorsFoxp1 protein, mouseFoxp2 protein, mouseIntracellular Signaling Peptides and ProteinsMcrip1 protein, mousePulmonary Surfactant-Associated Protein BPulmonary Surfactant-Associated Protein CRepressor ProteinsDevelopmentDifferentiationGene silencing

Identifiers

PMID31240265
PMCPMC6586819
OpenAlexW2952653423

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.