ArticleCommunications biology2019
MicroTools enables automated quantification of capillary density and red blood cell velocity in handheld vital microscopy.
Article in Communications biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07184476 (Assessment of Microvascular Circulation in the Pediatric Cardiac Surgery Patient), which is not on this map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Assessment of Microvascular Circulation in the Pediatric Cardiac Surgery Patient
Who cites it
44 citing papers in PubMed, 89 citations in OpenAlex.
- A Data-Efficient Computational Framework for Reconstruction and Simulation of Microcirculatory Perfusion.Microcirculation (New York, N.Y. : 1994) · 2026Article
- The OxyCam: A novel hand-held vital microscope for quantitative measurement of microcirculatory perfusion and oxygenation.Journal of intensive medicine · 2026Article
- In vivo mitochondrial oxygen consumption during LPS-induced endotoxemia: a controlled experimental study in swine.Intensive care medicine experimental · 2026Article
- Microcirculatory response and leukocyte activation in patients undergoing elective cardiac surgery with cardiopulmonary bypass.Journal of intensive medicine · 2026Article
- Beyond blood pressure: a comprehensive overview of clinical indices in shock and tissue hypoperfusion.Acute and critical care · 2026Article
- Microcirculatory perfusion is improved with plasma, but not with crystalloids, in a rat polytraumatic shock model.Transfusion · 2026Article
- Protective Effects of Pentoxifylline on Peripheral Microcirculatory Dysfunction and Renal Cortical Oxygen Deficiency in a Rat Model of LPS-Induced Sepsis.Microcirculation (New York, N.Y. : 1994) · 2026Article
- Improved Detection of Capillaries in High-Resolution Handheld Vital Microscopy by Use of the MicroTools Advanced Computer Vision Algorithm.Microcirculation (New York, N.Y. : 1994) · 2026Article
- Bedside measurement of microcirculation in critically ill patients: A scoping review protocol.PloS one · 2026Article
- Biomarkers of Microcirculatory Dysfunction in Sepsis: A Pilot Prospective Observational Study.Critical care explorations · 2025Observational
- The effect of major abdominal surgery on the sublingual microcirculation: an observational study.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2025Observational
- Visualizing hemodynamics: innovative graphical displays and imaging techniques in anesthesia and critical care.Critical care (London, England) · 2025Review
- Microcirculatory depth of focus measurement shows reduction of tissue edema by albumin resuscitation in burn patients.Journal of intensive medicine · 2025Article
- Nitroglycerin challenge identifies microcirculatory target for improved resuscitation in patients with circulatory shock.Intensive care medicine experimental · 2024Article
- The physiological basis for individualized oxygenation targets in critically ill patients with circulatory shock.Intensive care medicine experimental · 2024Review
- The microcirculation in the first days of ICU admission in critically ill COVID-19 patients is influenced by severity of disease.Scientific reports · 2024Article
- Interobserver reliability for manual analysis of sidestream darkfield videomicroscopy clips after resizing in ImageJ.Intensive care medicine experimental · 2023Article
- Microcirculatory Monitoring in Children with Congenital Heart Disease Before and After Cardiac Surgery.Journal of cardiovascular translational research · 2023Observational
- Intra-renal microcirculatory alterations on non-traumatic hemorrhagic shock induced acute kidney injury in pigs.Journal of clinical monitoring and computing · 2023Article
- Impairment of Mesenteric Perfusion as a Marker of Major Bleeding in Trauma Patients.Journal of clinical medicine · 2023Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Direct assessment of capillary perfusion has been prioritized in hemodynamic management of critically ill patients in addition to optimizing blood flow on the global scale. Sublingual handheld vital microscopy has enabled online acquisition of moving image sequences of the microcirculation, including the flow of individual red blood cells in the capillary network. However, due to inherent content complexity, manual image sequence analysis remained gold standard, introducing inter-observer variability and precluding real-time image analysis for clinical therapy guidance. Here we introduce an advanced computer vision algorithm for instantaneous analysis and quantification of morphometric and kinetic information related to capillary blood flow in the sublingual microcirculation. We evaluated this technique in a porcine model of septic shock and resuscitation and cardiac surgery patients. This development is of high clinical relevance because it enables implementation of point-of-care goal-directed resuscitation procedures based on correction of microcirculatory perfusion in critically ill and perioperative patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.