ArticleNature communications2019
Circuit asymmetries underlie functional lateralization in the mouse auditory cortex.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Self-vocalizations activate the developing auditory cortex via an intracortical pathway.Science advances · 2026Article
- Maternal experience alters brain-wide representation of infant cries.bioRxiv : the preprint server for biology · 2026Article
- Logistic regression for estimating functional effects with spatial transcriptomics.Nucleic acids research · 2026Article
- Aging in the Primary Auditory Cortex.Journal of the Association for Research in Otolaryngology : JARO · 2026Review
- Dysfunctional neural dynamics associated with sensory phenotypes in Fragile X syndrome: insights from mouse models.Journal of neurodevelopmental disorders · 2025Review
- Asynchronous development of the mouse auditory cortex is driven by hemispheric identity and sex.Nature communications · 2025Article
- Hemispheric Asymmetry of Intracortical Myelin Orientation in the Mouse Auditory Cortex.The European journal of neuroscience · 2025Article
- Developmental encoding of natural sounds in the mouse auditory cortex.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- NEATmap: a high-efficiency deep learning approach for whole mouse brain neuronal activity trace mapping.National science review · 2024Article
- Bilateral widefield calcium imaging reveals circuit asymmetries and lateralized functional activation of the mouse auditory cortex.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Sex, strain, and lateral differences in brain cytoarchitecture across a large mouse population.eLife · 2023Article
- Differences in temporal processing speeds between the right and left auditory cortex reflect the strength of recurrent synaptic connectivity.PLoS biology · 2022Article
- Lessons from behavioral lateralization in olfaction.Brain structure & function · 2022Review
- The Laterality of Age-related Hearing Loss and Cognition.Otology & neurotology open · 2022Article
- Topographically organized representation of space and context in the medial prefrontal cortex.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Hemispheric and Sex Differences in Mustached Bat Primary Auditory Cortex Revealed by Neural Responses to Slow Frequency Modulations.Symmetry · 2021Article
- Development of Auditory Cortex Circuits.Journal of the Association for Research in Otolaryngology : JARO · 2021Review
- Intraperitoneal injection of lithium chloride induces lateralized activation of the insular cortex in adult mice.Molecular brain · 2021Article
- Light sheet microscopy of the gerbil cochlea.The Journal of comparative neurology · 2021Article
- An Auditory Phantom Percept That Does Not Impair External Sound Perception.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The left hemisphere's dominance in processing social communication has been known for over a century, but the mechanisms underlying this lateralized cortical function are poorly understood. Here, we compare the structure, function, and development of each auditory cortex (ACx) in the mouse to look for specializations that may underlie lateralization. Using Fos brain volume imaging, we found greater activation in the left ACx in response to vocalizations, while the right ACx responded more to frequency sweeps. In vivo recordings identified hemispheric differences in spectrotemporal selectivity, reinforcing their functional differences. We then compared the synaptic connectivity within each hemisphere and discovered lateralized circuit-motifs that are hearing experience-dependent. Our results suggest a specialist role for the left ACx, focused on facilitating the detection of specific vocalization features, while the right ACx is a generalist with the ability to integrate spectrotemporal features more broadly.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.