Evidence map›Paper›PMID 31239378›Full record

ArticlemBio2019

Two Accessory Proteins Govern MmpL3 Mycolic Acid Transport in Mycobacteria.

Allison Fay, Nadine Czudnochowski, Jeremy M Rock, Jeffrey R Johnson, Nevan J Krogan, Oren Rosenberg, Michael S Glickman

Open access · goldAbstract read
In one paragraph

Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 52 citations in OpenAlex.

  1. Structure, assembly, and mechanism of the MmpL family of transporters.Microbiology and molecular biology reviews : MMBR · 2026
    Review
  2. Article
  3. Journal of bacteriology · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Molecular Mechanisms of MmpL3 Function and Inhibition.Microbial drug resistance (Larchmont, N.Y.) · 2023
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Allison FayImmunology Program, Sloan Kettering Institute, New York, New York, USA.
Nadine CzudnochowskiProgram for Microbial Pathogenesis, University of California, San Francisco, San Francisco, California, USA.
Jeremy M RockLaboratory of Host-Pathogen Biology, The Rockefeller University, New York, New York, USA.
Jeffrey R JohnsonDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, California, USA.
Nevan J KroganDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, California, USA.
Oren RosenbergProgram for Microbial Pathogenesis, University of California, San Francisco, San Francisco, California, USA.
Michael S GlickmanImmunology Program, Sloan Kettering Institute, New York, New York, USA glickmam@mskcc.org.ORCID 0000-0001-7918-5164
Gladstone Institutes · USUniversity of California, San Francisco · USKettering University · USMemorial Sloan Kettering Cancer Center · USRockefeller University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Viable but Nonculturable MtbU19AI111143 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI CASANOVA, JEAN-LAURENT, GLICKMAN, MICHAEL S · 2014 to 2020
$48.6M
The role of Listeria cyclic-di-AMP during infection and immunityP01AI063302 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI STANLEY, SARAH A · 2004 to 2025
$45.5M
RESEARCH PROJECT 2U19AI135990 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Nevan J Krogan · 2018 to 2026
$21.4M
Vulnerabilities in Mycobacterial Cell-Wall BiogenesisP01AI095208 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI ZHANG, JUNJIE · 2012 to 2022
$19.8M
Discovery of novel, ubiquitin-regulated mechanisms of TB control by macrophagesR01AI120694 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COX, JEFFERY S, KROGAN, NEVAN J · 2015 to 2019
$3.3M
Protein secretion in bacterial pathogensR01AI128214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GROSS, CAROL ANNE · 2017 to 2021
$2.0M
NCI NIH HHS P30 CA008748NIAID NIH HHS P01 AI063302NIAID NIH HHS P01 AI095208NIAID NIH HHS R01 AI120694NIAID NIH HHS R01 AI128214NIAID NIH HHS U19 AI135990
6 · The paper itself

Abstract

Mycolic acids are the signature lipid of mycobacteria and constitute an important physical component of the cell wall, a target of mycobacterium-specific antibiotics and a mediator of

Indexed as

Bacterial ProteinsCell MembraneCell WallMembrane Transport ProteinsMycobacterium smegmatisMycobacterium tuberculosisMycolic AcidsBacterial ProteinsMembrane Transport ProteinsMmpL3 protein, Mycobacterium tuberculosisMycolic Acidscell envelopeMycobacteriumMycobacterium tuberculosistransporters

Identifiers

PMID31239378
PMCPMC6593404
OpenAlexW2954810968

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.