ArticleProceedings of the National Academy of Sciences of the United States of America2019
Dissecting fat-tailed fluctuations in the cytoskeleton with active micropost arrays.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Micropillars in Cell Mechanobiology: Design, Fabrication, Characterization, and Biosensing Applications.Small science · 2025Review
- Nucleation causes an actin network to fragment into multiple high-density domains.Biophysical journal · 2022Article
- Measuring Cytoskeletal Mechanical Fluctuations and Rheology with Active Micropost Arrays.Current protocols · 2022Article
- Understanding cytoskeletal avalanches using mechanical stability analysis.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- AFM and Fluorescence Microscopy of Single Cells with Simultaneous Mechanical Stimulation via Electrically Stretchable Substrates.Materials (Basel, Switzerland) · 2021Article
- Force-dependent trans-endocytosis by breast cancer cells depletes costimulatory receptor CD80 and attenuates T cell activation.Biosensors & bioelectronics · 2020Article
- The role of the Arp2/3 complex in shaping the dynamics and structures of branched actomyosin networks.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
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Authors and funding
4 authors.
Funding
Abstract
The ability of animal cells to crawl, change their shape, and respond to applied force is due to their cytoskeleton: A dynamic, cross-linked network of actin protein filaments and myosin motors. How these building blocks assemble to give rise to cells' mechanics and behavior remains poorly understood. Using active micropost array detectors containing magnetic actuators, we have characterized the mechanics and fluctuations of cells' actomyosin cortex and stress fiber network in detail. Here, we find that both structures display remarkably consistent power law viscoelastic behavior along with highly intermittent fluctuations with fat-tailed distributions of amplitudes. Notably, this motion in the cortex is dominated by occasional large, step-like displacement events, with a spatial extent of several micrometers. Overall, our findings for the cortex appear contrary to the predictions of a recent active gel model, while suggesting that different actomyosin contractile units act in a highly collective and cooperative manner. We hypothesize that cells' actomyosin components robustly self-organize into marginally stable, plastic networks that give cells' their unique biomechanical properties.
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