ArticleProceedings of the National Academy of Sciences of the United States of America2019
Consecutive seeding and transfer of genetic diversity in metastasis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed, 2 citations in OpenAlex.
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- Evolutionary paths towards metastasis.Nature reviews. Cancer · 2025Review
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- Modeling tumors as complex ecosystems.iScience · 2024Review
- Modeling tumors as species-rich ecological communities.bioRxiv : the preprint server for biology · 2024Article
- Onco-Breastomics: An Eco-Evo-Devo Holistic Approach.International journal of molecular sciences · 2024Review
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- Intermetastatic and Intrametastatic Heterogeneity Shapes Adaptive Therapy Cycling Dynamics.Cancer research · 2023Article
- Integrative multi-omics and drug-response characterization of patient-derived prostate cancer primary cells.Signal transduction and targeted therapy · 2023Article
- Agent-based methods facilitate integrative science in cancer.Trends in cell biology · 2023Review
- Inferring parameters of cancer evolution in chronic lymphocytic leukemia.PLoS computational biology · 2022Article
- Article
- Immunogenomic intertumor heterogeneity across primary and metastatic sites in a patient with lung adenocarcinoma.Journal of experimental & clinical cancer research : CR · 2022Article
- Review
- Single-cell transcriptomics links malignant T cells to the tumor immune landscape in cutaneous T cell lymphoma.Nature communications · 2022Article
- Cancer metastasis is related to normal tissue stemness.PloS one · 2022Article
- Multiparametric Circulating Tumor Cell Analysis to Select Targeted Therapies for Breast Cancer Patients.Cancers · 2021Article
- Models of pancreatic ductal adenocarcinoma.Cancer metastasis reviews · 2021Review
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
During metastasis, only a fraction of genetic diversity in a primary tumor is passed on to metastases. We calculate this fraction of transferred diversity as a function of the seeding rate between tumors. At one extreme, if a metastasis is seeded by a single cell, then it inherits only the somatic mutations present in the founding cell, so that none of the diversity in the primary tumor is transmitted to the metastasis. In contrast, if a metastasis is seeded by multiple cells, then some genetic diversity in the primary tumor can be transmitted. We study a multitype branching process of metastasis growth that originates from a single cell but over time receives additional cells. We derive a surprisingly simple formula that relates the expected diversity of a metastasis to the diversity in the pool of seeding cells. We calculate the probability that a metastasis is polyclonal. We apply our framework to published datasets for which polyclonality has been previously reported, analyzing 68 ovarian cancer samples, 31 breast cancer samples, and 8 colorectal cancer samples from 15 patients. For these clonally diverse metastases, under typical metastasis growth conditions, we find that 10 to 150 cells seeded each metastasis and left surviving lineages between initial formation and clinical detection.
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